# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4052329 | Binding | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | ALA4049456 | cell-based format | Scientific Literature | |
2. | ALA4052332 | Binding | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | ALA4049456 | cell-based format | Scientific Literature | |
3. | ALA4052333 | Binding | Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition in presence of 0.1% BSA measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | ALA4049456 | cell-based format | Scientific Literature | |
4. | ALA4052334 | Binding | Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay | Homo sapiens | 30 | ALA4049456 | assay format | Scientific Literature | |
5. | ALA4052335 | ADME | Cmax in C57BL/6 mouse lung at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | ALA4049456 | organism-based format | Scientific Literature | |
6. | ALA4052336 | ADME | Cmax in C57BL/6 mouse plasma at 30 mg/kg, po by LC-MS/MS analysis | Mus musculus | 12 | ALA4049456 | organism-based format | Scientific Literature | |
7. | ALA4052343 | Binding | Irreversible inhibition of human LOXL2 assessed as reduction of H2O2 production from oxidative deamination of DAP at 1000 times IC50 preincubated for 2 hrs followed by compound washout and subsequent incubation for 2 hrs prior to substrate addition measured every 2 mins for 40 mins by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | ALA4049456 | single protein format | Scientific Literature | |
8. | ALA4052344 | Binding | Irreversible inhibition of human LOXL2 assessed as catalytic activity preincubated for 2 hrs followed by substrate addition measured every 2 mins for 1 hr by amplex red reagent-based fluorescence assay relative to control | Homo sapiens | 10 | ALA4049456 | single protein format | Scientific Literature | |
9. | ALA4418378 | Binding | Inhibition of human LOXL2 expressed in CHO cells assessed as reduction in amine oxidase activity incubated for 2 hrs by Amplex red based fluorescence assay | Homo sapiens | 120 | ALA4418283 | cell-based format | Patent Bioactivity Data |