| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4052063 | Toxicity | Genotoxicity in Salmonella typhimurium TAT1535 in presence of rat liver S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | ALA4049449 | assay format | Scientific Literature | |
| 2. | ALA4052064 | Toxicity | Genotoxicity in Salmonella typhimurium TA97 in presence of rat liver S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | ALA4049449 | assay format | Scientific Literature | |
| 3. | ALA4052065 | Toxicity | Genotoxicity in Salmonella typhimurium TA98 in presence of rat liver S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | ALA4049449 | assay format | Scientific Literature | |
| 4. | ALA4052066 | Toxicity | Genotoxicity in Salmonella typhimurium TA100 in presence of rat liver S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | ALA4049449 | assay format | Scientific Literature | |
| 5. | ALA4052067 | Toxicity | Genotoxicity in Salmonella typhimurium TA102 in presence of rat liver S9 fraction by Ames test | Salmonella enterica subsp. enterica serovar Typhimurium | 9 | ALA4049449 | assay format | Scientific Literature | |
| 6. | ALA4478549 | ADME | Stability in human plasma assessed as compound remaining after 5 hrs | Homo sapiens | 4 | ALA4477215 | cell-free format | Scientific Literature | |
| 7. | ALA4478557 | Functional | Phototoxicity in mouse 3T3 cells in presence of UVA irradiation | Mus musculus | 3 | ALA4477215 | cell-based format | Scientific Literature | |
| 8. | ALA4478614 | Binding | Inhibition of mRNA splicing of SMN2 exon 7 in GM03813 fibroblasts derived from SMA patient assessed as compound concentration required to increase SMN protein level by 1.5 times after 24 hrs by HTRF assay | Homo sapiens | 59 | ALA4477216 | assay format | Scientific Literature | |
| 9. | ALA4478616 | ADME | Apparent permeability in human Caco2 cells | Homo sapiens | 7 | ALA4477216 | cell-based format | Scientific Literature | |
| 10. | ALA4478617 | ADME | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in human Caco2 cells | Homo sapiens | 7 | ALA4477216 | cell-based format | Scientific Literature | |
| 11. | ALA4478618 | ADME | Protein binding in human plasma | Homo sapiens | 7 | ALA4477216 | cell-free format | Scientific Literature | |
| 12. | ALA4478619 | ADME | AUC (0 to 6 hrs) in Sprague-Dawley rat at 10 mg/kg, po | Rattus norvegicus | 11 | ALA4477216 | organism-based format | Scientific Literature | |
| 13. | ALA4478620 | ADME | Ratio of drug level in brain to plasma of Sprague-Dawley rat at 10 mg/kg, po measured at 6 hrs | Rattus norvegicus | 11 | ALA4477216 | organism-based format | Scientific Literature | |
| 14. | ALA4478621 | ADME | AUC (0 to 24 hrs) in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse at 10 mg/kg, ip | Mus musculus | 3 | ALA4477216 | organism-based format | Scientific Literature | |
| 15. | ALA4478622 | ADME | Ratio of drug level in brain to plasma of FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse at 10 mg/kg, ip | Mus musculus | 3 | ALA4477216 | organism-based format | Scientific Literature | |
| 16. | ALA4478623 | Functional | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as increase in SMN protein level in brain at 0.03 mg/kg, ip qd administered on postnatal day 3 to day 9 by HTRF assay relative to control | Mus musculus | 1 | ALA4477216 | organism-based format | Scientific Literature | |
| 17. | ALA4478624 | Functional | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as increase in SMN protein level in spinal cord at 0.03 mg/kg, ip qd administered on postnatal day 3 to day 9 by HTRF assay relative to control | Mus musculus | 1 | ALA4477216 | organism-based format | Scientific Literature | |
| 18. | ALA4478625 | Functional | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as increase in SMN protein level in quadriceps at 0.03 mg/kg, ip qd administered on postnatal day 3 to day 9 by HTRF assay relative to control | Mus musculus | 1 | ALA4477216 | organism-based format | Scientific Literature | |
| 19. | ALA4478626 | Functional | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as median survival time at 0.1 mg/kg/day, ip administered on postnatal day 3 to day 23 (Rvb = 14 days) | Mus musculus | 2 | ALA4477216 | organism-based format | Scientific Literature | |
| 20. | ALA4478627 | Functional | In vivo inhibition of mRNA splicing of human SMN2 exon 7 in FVB.Cg-Tg(SMN2 delta 7 exon)4299Ahmb Tg(SMN2)89Ahmb Smn1tm1Msd/J mouse assessed as median survival time at 0.3 mg/kg/day, ip administered on postnatal day 3 to day 23 (Rvb = 14 days) | Mus musculus | 2 | ALA4477216 | organism-based format | Scientific Literature |
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