| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4058859 | B | Allosteric modulation of urotensin-2 receptor in Sprague-Dawley rat thoracic aorta assessed as change in human urotensin-2-mediated aortic ring contraction by measuring urotensin-2 Emax at 10'-5M preincubated for 15 mins followed by urotensin-2 addition relative to KCl (Rvb = 103 +/- 2%) | Rattus norvegicus | 26 | single protein format | Scientific Literature | ||
| 2. | ALA4058861 | B | Allosteric modulation of urotensin-2 receptor in Sprague-Dawley rat thoracic aorta assessed as change in human urotensin-2-mediated aortic ring contraction by measuring urotensin-2 pEC50 at 10'-5M preincubated for 15 mins followed by urotensin-2 addition (Rvb = 8.61 +/- 0.05 No_unit) | Rattus norvegicus | 26 | single protein format | Scientific Literature | ||
| 3. | ALA4058863 | B | Allosteric modulation of urotensin-2 receptor in Sprague-Dawley rat thoracic aorta assessed as change in URP-mediated aortic ring contraction by measuring URP Emax at 10'-5M preincubated for 15 mins followed by URP addition relative to KCl (Rvb = 118 +/- 2%) | Rattus norvegicus | 26 | single protein format | Scientific Literature | ||
| 4. | ALA4058865 | B | Allosteric modulation of urotensin-2 receptor in Sprague-Dawley rat thoracic aorta assessed as change in URP-mediated aortic ring contraction by measuring URP pEC50 at 10'-5M preincubated for 15 mins followed by URP addition (Rvb = 8.09 +/- 0.03 No_unit) | Rattus norvegicus | 26 | single protein format | Scientific Literature | ||
| 5. | ALA4058867 | B | Agonist activity at urotensin-2 receptor in Sprague-Dawley rat thoracic aorta assessed as induction of aortic ring contraction at 10'-5 M incubated for 15 mins | Rattus norvegicus | 26 | single protein format | Scientific Literature | ||
| 6. | ALA4058868 | B | Agonist activity at human urotensin-2 receptor expressed in HEK293 cells assessed as Gq activation at 10'-5 M incubated for 30 mins by BRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 7. | ALA4058869 | B | Agonist activity at human urotensin-2 receptor expressed in HEK293 cells assessed as G12 activation at 10'-5 M incubated for 30 mins by BRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 8. | ALA4058870 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in human urotensin-2-induced Gq activation by measuring urotensin-2 Emax at 10'-5 M preincubated for 30 mins followed by urotensin-2 addition by BRET assay (Rvb = 100 +/- 3%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 9. | ALA4058871 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in human urotensin-2-induced Gq activation by measuring urotensin-2 pEC50 at 10'-5 M preincubated for 30 mins followed by urotensin-2 addition by BRET assay (Rvb = 7.88 +/- 0.07 No_unit) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4058872 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in URP-induced Gq activation by measuring URP Emax at 10'-5 M preincubated for 30 mins followed by URP addition by BRET assay (Rvb = 100 +/- 3%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4058873 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in URP-induced Gq activation by measuring URP pEC50 at 10'-5 M preincubated for 30 mins followed by URP addition by BRET assay (Rvb = 8.28 +/- 0.08 No_unit) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4058874 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in human urotensin-2-induced G12 activation by measuring urotensin-2 Emax at 10'-5 M preincubated for 30 mins followed by urotensin-2 addition by BRET assay (Rvb = 100 +/- 6%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4058875 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in human urotensin-2-induced G12 activation by measuring urotensin-2 pEC50 at 10'-5 M preincubated for 30 mins followed by urotensin-2 addition by BRET assay (Rvb = 6.31 +/- 0.17 No_unit) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4058876 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in URP-induced G12 activation by measuring URP Emax at 10'-5 M preincubated for 30 mins followed by URP addition by BRET assay (Rvb = 100 +/- 7%) | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 15. | ALA4058877 | B | Allosteric modulation of human urotensin-2 receptor expressed in HEK293 cells assessed as change in URP-induced G12 activation by measuring URP pEC50 at 10'-5 M preincubated for 30 mins followed by URP addition by BRET assay (Rvb = 6.75 +/- 0.19 No_unit) | Homo sapiens | 4 | cell-based format | Scientific Literature |
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