# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4364724 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | ALA4364247 | subcellular format | Scientific Literature | |
2. | ALA4364725 | Binding | Selectivity index, ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 15 | ALA4364247 | assay format | Scientific Literature | |
3. | ALA4364727 | Binding | Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 15 | ALA4364247 | assay format | Scientific Literature | |
4. | ALA4364728 | Binding | Inhibition of recombinant mouse 17beta-HSD1 expressed in HEK293 cells at 1 uM using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis relative to control | Mus musculus | 6 | ALA4364247 | cell-based format | Scientific Literature | |
5. | ALA4364732 | ADME | Half life in human liver S9 fraction at 1 uM in presence of NADPH | Homo sapiens | 14 | ALA4364247 | subcellular format | Scientific Literature | |
6. | ALA4364733 | Physicochemical | Aqueous solubility of the compound in phosphate-buffered saline at pH 7.2 after 1 to 24 hrs | 11 | ALA4364247 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA3995154 | Binding | Inhibition of human placental cytosolic 17beta-HSD1 assessed as reduction in activation of [2,4,6,7-3H]-E1 substrate to E2 after 10 mins in presence of NADH by RP-HPLC method | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
8. | ALA3995155 | Binding | Inhibition of human placental microsomal 17beta-HSD2 using [2,4,6,7-3H]-E2 as substrate after 20 mins in presence of NAD+ by RP-HPLC method | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
9. | ALA3995156 | Binding | Selectivity ratio of IC50 for human placental microsomal 17beta-HSD2 to IC50 for human placental cytosolic 17beta-HSD1 | Homo sapiens | 32 | ALA3994586 | assay format | Scientific Literature | |
10. | ALA3995157 | ADME | Displacement of [3H]E2 from human recombinant ERalpha assessed as receptor binding at 3 uM after 16 to 20 hrs by liquid scintillation counting method relative to control | Homo sapiens | 8 | ALA3994586 | single protein format | Scientific Literature | |
11. | ALA3995158 | ADME | Displacement of [3H]E2 from human recombinant ERbeta assessed as receptor binding at 10 uM after 16 to 20 hrs by liquid scintillation counting method relative to control | Homo sapiens | 8 | ALA3994586 | single protein format | Scientific Literature |