| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993207 | B | Positive allosteric modulation of human glycine alpha3beta receptor expressed in HEK293T cells assessed as compound concentration required to induce up to 3-fold leftward shift in glycine-induced increase in chloride ion flux after 4 mins by Schild plot analysis | Homo sapiens | 35 | cell-based format | Scientific Literature | ||
| 2. | ALA3993230 | B | Positive allosteric modulation of human glycine alpha3 receptor expressed in HEK293T cells assessed as potentiation of glycine-induced increase in chloride ion flux after 4 mins by membrane potential blue dye based FLIPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA3993231 | B | Binding affinity to human glycine alpha3 receptor expressed in HEK293T cells by SPR assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA3993232 | F | Antiallodynic activity in mouse model of spared nerve injury-induced tactile allodynia assessed as tactile threshold at 20 mg/kg, po measured 60 mins post dose by Von Frey filament assay (Rvb = 0.82 +/- 0.19 g) | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 5. | ALA3993237 | U | Ratio of unbound Cmax in mouse brain to EC50 for glycine alpha3 receptor in mouse model of spared nerve injury-induced tactile allodynia at 20 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature |
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