# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3995357 | Binding | Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 10 | ALA3994596 | assay format | Scientific Literature | |
2. | ALA3995360 | Binding | Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 10 | ALA3994596 | assay format | Scientific Literature | |
3. | ALA3995362 | Binding | Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 10 | ALA3994596 | assay format | Scientific Literature | |
4. | ALA3995363 | Binding | Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 8 | ALA3994596 | assay format | Scientific Literature | |
5. | ALA3995364 | Binding | Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 6 | ALA3994596 | assay format | Scientific Literature | |
6. | ALA3995366 | Binding | Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 9 | ALA3994596 | assay format | Scientific Literature | |
7. | ALA3995367 | Binding | Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 10 | ALA3994596 | assay format | Scientific Literature | |
8. | ALA3995370 | Binding | Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 9 | ALA3994596 | assay format | Scientific Literature | |
9. | ALA3995371 | Binding | Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay | Homo sapiens | 8 | ALA3994596 | assay format | Scientific Literature | |
10. | ALA4495582 | Functional | SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate | Severe acute respiratory syndrome coronavirus 2 | 7,212 | ALA4495564 | assay format | SARS-CoV-2 Screening Data 2020-21 | |
11. | ALA4513082 | Functional | Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 7,212 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
12. | ALA4513083 | Functional | Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging | Chlorocebus sabaeus | 147 | ALA4495565 | organism-based format | SARS-CoV-2 Screening Data 2020-21 | |
13. | ALA4513084 | Toxicity | Toxicity CC50 against VERO-E6 cells determined at 48 hours by high content imaging (same conditions as 2_LEY without exposure to 0.01 MOI SARS CoV-2 virus) | Chlorocebus sabaeus | 147 | ALA4495565 | cell-based format | SARS-CoV-2 Screening Data 2020-21 | |
14. | ALA4513085 | Toxicity | Cytotoxicity index (CI): selectivity for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells versus toxicity against VERO-E6 cells (CC50/IC50) | Chlorocebus sabaeus | 147 | ALA4495565 | cell-based format | SARS-CoV-2 Screening Data 2020-21 | |
15. | ALA5227351 | ADME | Efflux ratio of apparent permeability in human Caco-2 cells | Homo sapiens | 1 | ALA5226302 | cell-based format | Scientific Literature | |
16. | ALA5303712 | Functional | Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGFP-labeled Green monkey Vero cells by fluorescence imaging. | Chlorocebus sabaeus | 134 | ALA5303708 | organism-based format | EU-OPENSCREEN dataset | |
17. | ALA5303715 | Toxicity | Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay. | Homo sapiens | 1,545 | ALA5303711 | cell-based format | EU-OPENSCREEN dataset |