| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4058229 | B | Displacement of [3H]-DAMGO from MOR in rat brain membranes by liquid scintillation counting analysis | Rattus norvegicus | 6 | ALA4052787 | cell membrane format | Scientific Literature | |
| 2. | ALA4058230 | B | Displacement of [3H]-DPDPE from DOR in rat brain membranes by liquid scintillation counting analysis | Rattus norvegicus | 6 | ALA4052787 | cell membrane format | Scientific Literature | |
| 3. | ALA4058231 | B | Displacement of [3H]-(+)-U69,593 from KOR in guinea pig brain membranes by liquid scintillation counting analysis | Cavia porcellus | 6 | ALA4052787 | cell membrane format | Scientific Literature | |
| 4. | ALA4058232 | B | Ratio of Ki for DOR in rat brain membranes to Ki for MOR in rat brain membranes | Rattus norvegicus | 5 | ALA4052787 | cell membrane format | Scientific Literature | |
| 5. | ALA4058233 | B | Ratio of Ki for KOR in guinea pig brain membranes to Ki for MOR in rat brain membranes | 5 | ALA4052787 | cell membrane format | Scientific Literature | ||
| 6. | ALA4058234 | B | Agonist activity at MOR/KOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of electrically induced contractions after 5 mins | Cavia porcellus | 5 | ALA4052787 | assay format | Scientific Literature | |
| 7. | ALA4058235 | B | Agonist activity at DOR in CD-1 mouse vasa deferentia assessed as inhibition of electrically induced contractions after 5 mins | Mus musculus | 5 | ALA4052787 | assay format | Scientific Literature | |
| 8. | ALA4058236 | B | Antagonist activity at MOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of electrically induced contractions after 5 mins by measuring ratio of IC50 for test compounds in presence and absence of NLX | Cavia porcellus | 4 | ALA4052787 | assay format | Scientific Literature | |
| 9. | ALA4058237 | B | Antagonist activity at KOR in Dunkin-Hartley guinea pig ileum assessed as inhibition of electrically induced contractions after 5 mins by measuring ratio of IC50 for test compounds in presence and absence of nBNI | Cavia porcellus | 4 | ALA4052787 | assay format | Scientific Literature | |
| 10. | ALA4058238 | B | Antagonist activity at DOR in CD-1 mouse vasa deferentia assessed as inhibition of electrically induced contractions after 5 mins by measuring ratio of IC50 for test compounds in presence and absence of nBNI | Mus musculus | 3 | ALA4052787 | assay format | Scientific Literature | |
| 11. | ALA4058240 | F | Antinociceptive activity in rat assessed as reduction in response to heat administered ip measured 240 mins post dose by tail-flick test | Rattus norvegicus | 3 | ALA4052787 | organism-based format | Scientific Literature | |
| 12. | ALA4058241 | F | Antinociceptive activity in rat assessed as reduction in response to heat administered ip measured 45 to 180 mins post dose by tail-flick test | Rattus norvegicus | 1 | ALA4052787 | organism-based format | Scientific Literature | |
| 13. | ALA4058242 | F | Antinociceptive activity in rat assessed as reduction in response to heat administered ip measured 60 mins post dose by tail-flick test | Rattus norvegicus | 2 | ALA4052787 | organism-based format | Scientific Literature | |
| 14. | ALA4058243 | F | Antinociceptive activity in rat assessed as reduction in response to heat pretreated with naloxone for 30 mins prior to compound treatment by tail-flick test | Rattus norvegicus | 3 | ALA4052787 | assay format | Scientific Literature | |
| 15. | ALA4058244 | B | Potency index, ratio of LP1 Ki to compound Ki for KOR in guinea pig brain membranes | Cavia porcellus | 4 | ALA4052787 | cell membrane format | Scientific Literature | |
| 16. | ALA4341019 | B | Agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increase in MOR/G beta1 protein interaction incubated for 5 mins in presence of coelenterazine by BRET assay | Homo sapiens | 5 | ALA4340514 | cell-based format | Scientific Literature | |
| 17. | ALA4341020 | B | Agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to MOR/beta-arrestin-2 assessed as increase in MOR/beta-arrestin-2 protein interaction incubated for 5 mins in presence of coelenterazine by BRET assay | Homo sapiens | 3 | ALA4340514 | cell-based format | Scientific Literature | |
| 18. | ALA4341021 | B | Agonist activity at Rluc-tagged DOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 assessed as increase in DOR/G beta1 protein interaction incubated for 5 mins in presence of coelenterazine by BRET assay | Homo sapiens | 5 | ALA4340514 | cell-based format | Scientific Literature | |
| 19. | ALA4341022 | B | Agonist activity at Rluc-tagged DOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to beta-arrestin-2 assessed as increase in DOR/beta-arrestin-2 protein interaction incubated for 5 mins in presence of coelenterazine by BRET assay | Homo sapiens | 3 | ALA4340514 | cell-based format | Scientific Literature | |
| 20. | ALA4341023 | B | Potency index, ratio of test compounds EC50 to DADLE EC50 for agonist activity at Rluc-tagged MOR receptor (unknown origin) expressed in human SH-5YSY cells co-expressing RGFP-fused to Gbeta1 | Homo sapiens | 5 | ALA4340514 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!