| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4010769 | B | Inhibition of recombinant human TACE catalytic domain using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Ser-Arg-NH2 as substrate after 2 hrs by fluorescence assay | Homo sapiens | 40 | single protein format | Scientific Literature | ||
| 2. | ALA4010770 | A | Stability in human liver microsomes assessed as parent compound remaining at 1 uM after 15 mins by LC-MS/MS analysis | Homo sapiens | 13 | assay format | Scientific Literature | ||
| 3. | ALA4010771 | A | Inhibition of recombinant human MMP1 catalytic domain using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate after 10 mins by fluorescence assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4010772 | A | Inhibition of MMP3 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4010773 | A | Inhibition of MMP9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4010774 | A | Inhibition of MMP12 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4010775 | B | Inhibition of ADAM9 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4010776 | B | Inhibition of ADAM10 (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4010777 | B | Inhibition of TACE in NHEK assessed as reduction in LPS/TPA-stimulated TNFalpha production preincubated for 1 hr followed by LPS/TPA stimulation for 24 hrs by HTRF assay | Homo sapiens | 11 | single protein format | Scientific Literature | ||
| 10. | ALA4010778 | A | Fraction unbound in human plasma at 5 uM after 4 hrs by LC-MS/MS based equilibrium dialysis method | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 11. | ALA4010779 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM up to 90 mins by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4010780 | A | Half life in human keratinocytes at 1 uM by LC-MS/MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4010781 | P | Aqueous solubility of the compound | 11 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA4010782 | P | Solubility of the compound in PG/EtOH96 | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 15. | ALA4010783 | U | Photoirritancy factor, ratio of EC50 for human neonatal keratinocytes under dark condition to EC50 for human neonatal keratinocytes under 5 J/cm2 UV light exposure | Homo sapiens | 1 | cell-based format | Scientific Literature |
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