# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4043761 | Functional | Neuroprotective activity against fibril amyloid beta (25 to 35)-induced cell death in Sprague-Dawley rat 5 day old neonatal primary cortical neurons assessed as cell death at maximum non toxic concentration pretreated for 2 hrs followed by 10 uM fibril amyloid beta (25 to 35) addition measured after 48 hrs by MTT assay (Rvb = 39.20 +/- 0.88%) | Rattus norvegicus | 36 | ALA4043092 | cell-based format | Scientific Literature | |
2. | ALA4043762 | Functional | Neuroprotective activity against glutamate-induced cell death in Sprague-Dawley rat 10 days old neonatal primary cortical neurons assessed as cell death at maximum non toxic concentration pretreated for 2 hrs followed by 30 uM glutamate addition measured after 24 hrs by MTT assay (Rvb = 41.22 +/- 3.40%) | Rattus norvegicus | 36 | ALA4043092 | cell-based format | Scientific Literature | |
3. | ALA4043763 | Functional | Neuroprotective activity against fibril amyloid beta (25 to 35)-induced cell death in Sprague-Dawley rat 5 days old neonatal primary cortical neurons assessed as increase in cell viability pretreated for 2 hrs followed by 10 uM fibril amyloid beta (25 to 35) addition measured after 48 hrs by MTT assay | Rattus norvegicus | 13 | ALA4043092 | cell-based format | Scientific Literature | |
4. | ALA4043764 | Functional | Neuroprotective activity against glutamate-induced cell death in Sprague-Dawley rat 10 days old neonatal primary cortical neurons assessed as increase in cell viability pretreated for 2 hrs followed by 30 uM glutamate addition measured after 24 hrs by MTT assay | Rattus norvegicus | 13 | ALA4043092 | cell-based format | Scientific Literature | |
5. | ALA4043771 | Functional | Anti-inflammatory activity in Sprague-Dawley rat primary mixed glial cells assessed as inhibition of LPS-induced NO production at 50 uM pretreated for 2 hrs followed by LPS addition measured after 48 hrs by Griess assay (Rvb = 100%) | Rattus norvegicus | 36 | ALA4043092 | cell-based format | Scientific Literature | |
6. | ALA4043772 | Functional | Anti-inflammatory activity in Sprague-Dawley rat primary mixed glial cells assessed as inhibition of LPS-induced NO production pretreated for 2 hrs followed by LPS addition measured after 48 hrs by Griess assay | Rattus norvegicus | 13 | ALA4043092 | cell-based format | Scientific Literature | |
7. | ALA4043773 | Functional | Antioxidant activity assessed as ABTS radical cation scavenging activity by measuring trolox equivalents by spectrophotometric analysis | 13 | ALA4043092 | assay format | Scientific Literature | ||
8. | ALA4043774 | ADME | Inhibition of CYP3A4 in human liver microsomes | Homo sapiens | 13 | ALA4043092 | assay format | Scientific Literature |