# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4003670 | B | Inhibition of chymotrypsin-like activity of 20S proteasome in mouse blood at 0.5 uM pretreated for 40 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by fluorescence assay | Mus musculus | 4 | single protein format | Scientific Literature | ||
2. | ALA4003672 | B | Inhibition of chymotrypsin-like activity of human 20S proteasome pretreated for 15 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by fluorescence assay | Homo sapiens | 26 | single protein format | Scientific Literature | ||
3. | ALA4003673 | F | Cytotoxicity against human RPMI8226 cells measured after 72 hrs by MTS assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
4. | ALA4003674 | F | Cytotoxicity against human MM1S cells measured after 72 hrs by MTS assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
5. | ALA4003675 | B | Inhibition of chymotrypsin-like activity of 20S proteasome in mouse blood at 2.5 uM pretreated for 40 mins followed by Suc-Leu-Leu-Val-Tyr-AMC substrate addition by fluorescence assay relative to control | Mus musculus | 7 | single protein format | Scientific Literature | ||
6. | ALA5159800 | B | Inhibition of chymotrypsin-like activity of human 20S proteasome using Suc-Leu Leu-Val-Tyr-AMC as substrate preincubated for 15 mins followed by substrate addition measured by fluorescence assay | Homo sapiens | 34 | protein complex format | Scientific Literature | ||
7. | ALA5159801 | F | Antiproliferative activity against human RPMI-8226 cells after 72 hrs by MTS assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
8. | ALA5159802 | F | Antiproliferative activity against human MM1.S cells after 72 hrs by MTS assay | Homo sapiens | 14 | cell-based format | Scientific Literature | ||
9. | ALA5159805 | A | Stability of the compound in mouse blood assessed as half-life measured by LC-MS/MS analysis | Mus musculus | 4 | tissue-based format | Scientific Literature |