# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4009114 | F | Antitumor activity against human A549 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 15 mg/kg, iv administered every other day for 3 weeks measured twice per week during compound dosing | Homo sapiens | 1 | organism-based format | Scientific Literature | ||
2. | ALA4009115 | A | Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring ROS production at 10 uM after 1 to 3 hrs by DCFH-DA staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
3. | ALA4009117 | F | Antitumor activity against human A549 cells xenografted in athymic nude mouse assessed as tumor growth inhibition at 30 mg/kg, iv administered every other day for 3 weeks measured twice per week during compound dosing relative to control | Homo sapiens | 2 | organism-based format | Scientific Literature | ||
4. | ALA4009118 | T | Toxicity in athymic nude mouse xenografted with human A549 cells assessed as change in body weight at 15 to 30 mg/kg, iv administered every other day for 3 weeks measured twice per week during compound dosing | Mus musculus | 1 | organism-based format | Scientific Literature | ||
5. | ALA4009119 | T | Toxicity in athymic nude mouse xenografted with human A549 cells assessed as change in body weight at 30 mg/kg, iv administered every other day for 3 weeks measured twice per week during compound dosing | Mus musculus | 1 | organism-based format | Scientific Literature | ||
6. | ALA4009120 | B | Substrate activity at NQO1 in human A549 cells assessed as NQO1-mediated two-electron reduction of compound by measuring ROS production at 10 uM after 1 to 3 hrs in presence of ROS scavenger DIC by DCFH-DA staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4009121 | B | Substrate activity at NQO1 in human A549 cells assessed as NQO1-mediated two-electron reduction of compound by measuring ROS production at 10 uM after 1 to 3 hrs in presence of ROS scavenger NAC by DCFH-DA staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4009122 | B | Substrate activity at NQO1 in human H1650 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4009123 | F | Cytotoxicity against NQO1 inhibitor dicoumarol pretreated human A549 cells assessed as cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4009124 | F | Cytotoxicity against NQO1-deficient human NCI-H596 cells assessed as cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4009126 | B | Substrate activity at NQO1 in human A549 cells assessed as NQO1-mediated two-electron reduction of compound by measuring ROS production at 10 uM after 1 to 3 hrs by DCFH-DA staining based flow cytometry | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4009128 | A | Substrate activity at CPR in human L02 cells assessed as CPR-mediated one-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
13. | ALA4009129 | U | Selectivity ratio of IC50 for substrate activity at CPR in human L02 cells assessed as cell growth inhibition to IC50 for substrate activity at NQO1 in human A549 cells assessed as cell growth inhibition | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
14. | ALA4009130 | B | Substrate activity at NQO1 in human MCF7 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4009131 | B | Substrate activity at NQO1 in human HepG2 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4009132 | B | Substrate activity at NQO1 in human HCT116 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4009133 | B | Substrate activity at NQO1 in human H1299 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4009134 | B | Substrate activity at NQO1 in human H522 cells assessed as NQO1-mediated two-electron reduction of compound by measuring cell growth inhibition treated for 24 hrs measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4009135 | B | Substrate activity at recombinant human NQO1 expressed in Escherichia coli assessed as compound reduction rate by measuring NADPH consumption per umol of enzyme preincubated for 3 mins followed by NADPH addition measured for 5 mins at 2 sec time interval by UV-Visible spectroscopic method | Homo sapiens | 23 | assay format | Scientific Literature | ||
20. | ALA4009136 | A | Substrate activity at recombinant human CPR expressed in baculovirus infected insect cells assessed as compound reduction rate by measuring NADPH consumption per umol of enzyme preincubated for 3 mins followed by NADPH addition measured for 5 mins at 2 sec time interval by UV-Visible spectroscopic method | Homo sapiens | 23 | cell-based format | Scientific Literature |