# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA3997239 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assay | Rattus norvegicus | 27 | ALA3994648 | cell-based format | Scientific Literature | |
2. | ALA3997240 | A | Antagonist activity at human 5HT3A receptor assessed as inhibition of 5-HT-induced calcium influx by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 27 | ALA3994648 | single protein format | Scientific Literature | |
3. | ALA3997241 | U | Selectivity ratio of IC50 for antagonist activity at human 5HT3A receptor to EC50 for agonist activity at rat alpha7 nAChR expressed in HEK293 cells | 26 | ALA3994648 | cell-based format | Scientific Literature | ||
4. | ALA3997242 | B | Agonist activity at alpha4beta2 nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 27 | ALA3994648 | protein complex format | Scientific Literature | |
5. | ALA3997243 | B | Agonist activity at alpha3beta4 nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 27 | ALA3994648 | protein complex format | Scientific Literature | |
6. | ALA3997244 | B | Agonist activity at alpha1beta1deltaepsilon nAChR (unknown origin) assessed as increase in calcium influx measured for 2 mins by Fluo-4-AM dye based FLIPR assay | Homo sapiens | 27 | ALA3994648 | protein complex format | Scientific Literature | |
7. | ALA3997245 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells assessed as maximal peak response by patch clamp method relative to acetylcholine | Rattus norvegicus | 1 | ALA3994648 | cell-based format | Scientific Literature | |
8. | ALA3997246 | B | Intrinsic activity at rat alpha7 nAChR expressed in HEK293 cells assessed as maximal area response by patch clamp method relative to acetylcholine | Rattus norvegicus | 1 | ALA3994648 | cell-based format | Scientific Literature | |
9. | ALA3997247 | F | Cognitive enhancing effect in sc dosed mouse model of episodic memory assessed as increase in time spent exploring novel object over familiar object administered 30 mins prior to training measured after 24 hrs by novel object recognition assay | Mus musculus | 1 | ALA3994648 | organism-based format | Scientific Literature | |
10. | ALA3997248 | A | Plasma concentration in mouse at 0.3 mg/kg, po after 30 mins | Mus musculus | 1 | ALA3994648 | organism-based format | Scientific Literature | |
11. | ALA3997249 | A | Drug uptake in mouse brain at 0.3 mg/kg, po after 30 mins | Mus musculus | 1 | ALA3994648 | organism-based format | Scientific Literature | |
12. | ALA3997250 | B | Inhibition of human ERG by patch clamp electrophysiology assay | Homo sapiens | 2 | ALA3994648 | assay format | Scientific Literature | |
13. | ALA4004692 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells assessed as increase in Ca2+ flux by Fluo-4 AM dye based FLIPR assay | Rattus norvegicus | 4 | ALA4002647 | cell-based format | Scientific Literature | |
14. | ALA4004695 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as induction of peak current amplitutde at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Rattus norvegicus | 3 | ALA4002647 | cell-based format | Scientific Literature | |
15. | ALA4004696 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at 10 uM at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method relative to acetylcholine | Rattus norvegicus | 3 | ALA4002647 | cell-based format | Scientific Literature | |
16. | ALA4004697 | B | Agonist activity at rat alpha7 nAChR expressed in HEK293 cells co-expressing human RIC3 assessed as area under current curve at holding potential of -90 mV by whole-cell voltage clamp electrophysiology method | Rattus norvegicus | 3 | ALA4002647 | cell-based format | Scientific Literature | |
17. | ALA4004705 | A | Antagonist activity at human 5-HT3A receptor expressed in HEK293 cells | Homo sapiens | 3 | ALA4002647 | cell-based format | Scientific Literature | |
18. | ALA4004722 | B | Inhibition of human ERG potassium channel by patch clamp assay | Homo sapiens | 3 | ALA4002647 | assay format | Scientific Literature | |
19. | ALA4004731 | U | Selectivity index, ratio of IC50 for human 5-HT3A receptor expressed in HEK293 cells to EC50 for rat alpha7 nAChR expressed in HEK293 cells | 3 | ALA4002647 | cell-based format | Scientific Literature |