# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4030999 | B | Activation of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells measured after 30 hrs by dual luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
2. | ALA4031009 | A | Induction of necrosis in endothelin-1 induced neonatal rat ventricular cardiomyocytes assessed as release of adenylate kinase at 50 uM measured after 24 hrs by bioluminescence assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
3. | ALA4031010 | A | Induction of apoptosis in endothelin-1 induced neonatal rat ventricular cardiomyocytes at 50 uM measured after 24 hrs by TUNEL assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
4. | ALA4031029 | B | Activation of mouse GATA4/NKX2-5 transcriptional synergy expressed in African green monkey COS-1 cells at 10 uM measured after 30 hrs by dual luciferase reporter gene assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
5. | ALA4031030 | U | Induction of aggregation of compounds at 100 uM by nephalometric method | 3 | assay format | Scientific Literature | |||
6. | ALA4031031 | U | Induction of aggregation of compound at 30 uM by nephalometric method | 1 | assay format | Scientific Literature | |||
7. | ALA4031040 | B | Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of ANP at 20 uM after 24 hrs by real-time PCR analysis relative to control | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
8. | ALA4031041 | B | Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in basal mRNA level of BNP at 20 uM after 24 hrs by real-time PCR analysis relative to control | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
9. | ALA4031042 | B | Activation of GATA4/NKX2-5 interaction in neonatal rat ventricular cardiomyocytes assessed as increase in endothelin-1 induced mRNA level of BNP at 20 uM preincubated for 1 hr followed by endothelin-1 addition measured after 23 hrs by real-time PCR analysis relative to control | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
10. | ALA4031045 | A | Induction of necrosis in neonatal rat ventricular cardiomyocytes assessed as release of adenylate kinase at 50 uM measured after 24 hrs by bioluminescence assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
11. | ALA4322413 | B | Enhancement of mouse GATA4/mouse NKX2-5 protein-protein interaction expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as transcriptional synergy at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
12. | ALA4322415 | B | Enhancement of mouse NKX2-5 expressed in Chlorocebus aethiops COS1 cells harboring 3xHA reporter gene assessed as protein-induced transcriptional activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
13. | ALA4322417 | B | Enhancement of mouse GATA4 expressed in Chlorocebus aethiops COS1 cells harboring NP-112 reporter gene assessed as BNP promoter-driven transcriptional activity at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Mus musculus | 10 | cell-based format | Scientific Literature | ||
14. | ALA4322418 | B | Modulation of GATA4/NKX2-5 protein-protein interaction in neonatal Wistar rat cardiomyocytes harboring -534/+4 bp rat BNP proximal promoter assessed as increase in BNP-promoter driven activity at 10 to 30 preincubated for 1 hr followed by hypertrophic agonist endothelin-1 and measured after 24 hrs by luminescence method | Rattus norvegicus | 2 | cell-based format | Scientific Literature | ||
15. | ALA4322420 | A | Induction of necrosis in Chlorocebus aethiops COS1 cells assessed as LDH release at 1 to 30 uM after 24 hrs by LDH assay relative to control | Chlorocebus aethiops | 40 | cell-based format | Scientific Literature | ||
16. | ALA4322422 | A | Cytotoxicity against Chlorocebus aethiops COS1 cells assessed as reduction in cell viability at 10 uM after 24 hrs by CellTiter-Glo Luminescent Cell Viability assay relative to control | Chlorocebus aethiops | 6 | cell-based format | Scientific Literature |