| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4017368 | B | Inhibition of 5-FAM tracer binding to WDR5 delta23 mutant (24 to 334 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells after 3 hrs by fluorescence polarization assay | Homo sapiens | 19 | ALA4014355 | cell-based format | Scientific Literature | |
| 2. | ALA4017369 | B | Inhibition of human N-terminal GST-tagged MLL1 (3735 to 3973 residues) interaction with human full length N-terminal 6xHis-tagged ASH2L/N-terminal 6xHis-tagged human full length RbBP5/human N-terminal 6xHis-tagged WDR5/human full length N-terminal 6xHis-tagged DPY30 assessed as decrease in H3K4me1-2 methylation preincubated for 30 mins followed by SAM/nucleosome mixture addition measured after 120 mins in absence of light by AlphaLISA assay | Homo sapiens | 19 | ALA4014355 | protein format | Scientific Literature | |
| 3. | ALA4017370 | F | Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 4 days by WST8 assay | Homo sapiens | 15 | ALA4014355 | cell-based format | Scientific Literature | |
| 4. | ALA4017371 | F | Cytotoxicity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 4 days by WST8 assay | Homo sapiens | 15 | ALA4014355 | cell-based format | Scientific Literature | |
| 5. | ALA4017372 | A | Cytotoxicity against human HL60 cells lacking MLL translocation assessed as cell growth inhibition after 4 days by WST8 assay | Homo sapiens | 15 | ALA4014355 | cell-based format | Scientific Literature | |
| 6. | ALA4017373 | U | Selectivity ratio of IC50 for human HL60 cells lacking MLL translocation to IC50 for human MOLM13 cells harboring MLL-AF9 fusion protein | Homo sapiens | 3 | ALA4014355 | assay format | Scientific Literature | |
| 7. | ALA4017374 | U | Selectivity ratio of IC50 for human HL60 cells lacking MLL translocation to IC50 for human MV4-11 cells harboring MLL-AF4 fusion protein | Homo sapiens | 3 | ALA4014355 | assay format | Scientific Literature | |
| 8. | ALA4017375 | F | Cytotoxicity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition after 7 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 9. | ALA4017376 | F | Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition after 7 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 10. | ALA4017377 | F | Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition at 0.38 uM after 4 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 11. | ALA4017378 | F | Cytotoxicity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition at 0.69 uM after 4 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 12. | ALA4017379 | F | Cytotoxicity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition at 0.29 uM after 7 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 13. | ALA4017380 | F | Cytotoxicity against human MOLM13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition at 0.10 uM after 7 days by WST8 assay | Homo sapiens | 1 | ALA4014355 | cell-based format | Scientific Literature | |
| 14. | ALA4017381 | A | Half life in human microsomes | Homo sapiens | 9 | ALA4014355 | assay format | Scientific Literature | |
| 15. | ALA4017382 | A | Half life in rat microsomes | Rattus norvegicus | 9 | ALA4014355 | assay format | Scientific Literature | |
| 16. | ALA4017383 | A | Half life in mouse microsomes | Mus musculus | 9 | ALA4014355 | assay format | Scientific Literature | |
| 17. | ALA4017384 | U | Stability of compound in cell culture media at 0.5 mM after 7 days by Waters ACQUITY UPLC analysis | 1 | ALA4014355 | assay format | Scientific Literature | ||
| 18. | ALA4017385 | B | Inhibition of MLL2 (unknown origin) H3K4 methyltransferase activity using biotinyl-H3 peptide (1 to 21 residues) and using [3H]-S adenosylmethionine as methyl donor up to 100 uM after 1 hr by scintillation counting | Homo sapiens | 1 | ALA4014355 | single protein format | Scientific Literature | |
| 19. | ALA4017386 | B | Inhibition of MLL3 (unknown origin) H3K4 methyltransferase activity using biotinyl-H3 peptide (1 to 21 residues) and using [3H]-S adenosylmethionine as methyl donor up to 100 uM after 1 hr by scintillation counting | Homo sapiens | 1 | ALA4014355 | single protein format | Scientific Literature | |
| 20. | ALA4017387 | B | Inhibition of MLL4 (unknown origin) H3K4 methyltransferase activity using biotinyl-H3 peptide (1 to 21 residues) and using [3H]-S adenosylmethionine as methyl donor up to 100 uM after 1 hr by scintillation counting | Homo sapiens | 1 | ALA4014355 | single protein format | Scientific Literature |
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