| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4031179 | B | Binding affinity to human cGAS (2 to 522 residues) expressed in Sf9 insect cells by surface plasmon resonance assay | Homo sapiens | 6 | ALA4028860 | cell-based format | Scientific Literature | |
| 2. | ALA4031180 | B | Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presence of ATP and GTP after 30 mins by mass spectrometric analysis | Homo sapiens | 6 | ALA4028860 | cell-based format | Scientific Literature | |
| 3. | ALA4031181 | B | Inhibition of human cGAS (2 to 522 residues) expressed in Sf9 insect cells assessed as reduction in cGAMP level using ISD DNA as substrate in presence of ATP and GTP incubated for 1 hr followed by Cy5-labeled cGAMP addition measured after 1 hr by fluorescence polarization assay | Homo sapiens | 6 | ALA4028860 | cell-based format | Scientific Literature | |
| 4. | ALA4031182 | B | Inhibition of cGAS in human THP1 cells assessed as reduction in salmon sperm dsDNA-induced IFN-beta expression preincubated for 1 hr followed by dsDNA stimulation for 12 hrs by luciferase reporter gene assay | Homo sapiens | 5 | ALA4028860 | cell-based format | Scientific Literature | |
| 5. | ALA4031183 | A | Cytotoxicity against human THP1 cells assessed as reduction in cell viability by CellTiterGlo assay | Homo sapiens | 5 | ALA4028860 | cell-based format | Scientific Literature |
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