| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4029856 | B | Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation at 1 uM using PGH2 a substrate preincubated for 10 mins followed by substrate addition measured after 1 min relative to control | Homo sapiens | 18 | ALA4028818 | cell-based format | Scientific Literature | |
| 2. | ALA4029857 | B | Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation at 10 uM using PGH2 a substrate preincubated for 10 mins followed by substrate addition measured after 1 min relative to control | Homo sapiens | 18 | ALA4028818 | cell-based format | Scientific Literature | |
| 3. | ALA4029858 | B | Inhibition of recombinant human mPGES-1 expressed in CHO cells assessed as reduction in PGE2 formation using PGH2 a substrate preincubated for 10 mins followed by substrate addition measured after 1 min | Homo sapiens | 42 | ALA4028818 | cell-based format | Scientific Literature | |
| 4. | ALA4029859 | B | Inhibition of mPGES-1 in human A549 cells assessed as decrease in IL1beta induced PGE2 release preincubated for 30 mins followed by IL-1beta addition after 16 to 20 hrs by HTRF method | Homo sapiens | 18 | ALA4028818 | cell-based format | Scientific Literature | |
| 5. | ALA4029860 | A | Inhibition of COX1 in human U937 cells assessed as decrease in PGE2 release using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 5 mins | Homo sapiens | 3 | ALA4028818 | cell-based format | Scientific Literature | |
| 6. | ALA4029861 | A | Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 insect cells assessed as decrease in PGE2 release using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 5 mins | Homo sapiens | 3 | ALA4028818 | cell-based format | Scientific Literature | |
| 7. | ALA4029862 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 8. | ALA4029863 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Rattus norvegicus | 4 | ALA4028818 | assay format | Scientific Literature | |
| 9. | ALA4029864 | A | Metabolic stability in Guinea pig liver microsomes assessed as parent compound remaining at 1 uM after 60 mins in presence of NADPH by LC/MS/MS analysis | Cavia porcellus | 4 | ALA4028818 | assay format | Scientific Literature | |
| 10. | ALA4029865 | A | Inhibition of CYP1A2 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 11. | ALA4029866 | A | Inhibition of CYP2D6 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 12. | ALA4029867 | A | Inhibition of CYP3A4 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 13. | ALA4029868 | A | Inhibition of CYP2C9 in human liver microsomes at 10 uM measured after 20 mins in presence of NADPH by LC/MS/MS analysis relative to control | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 14. | ALA4029869 | A | Protein binding in human plasma at 10 uM after 5 to 10 mins by LC-MS/SM analsysis | Homo sapiens | 4 | ALA4028818 | cell-free format | Scientific Literature | |
| 15. | ALA4029870 | A | Protein binding in Guinea pig plasma at 10 uM after 5 to 10 mins by LC-MS/SM analysis | Cavia porcellus | 4 | ALA4028818 | cell-free format | Scientific Literature | |
| 16. | ALA4029882 | A | Inhibition of CYP2C19 in human liver microsomes at 1 uM measured after 40 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 4 | ALA4028818 | assay format | Scientific Literature | |
| 17. | ALA4029883 | A | Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 insect cells assessed as decrease in PGE2 release at 1 uM using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 5 mins relative to control | Homo sapiens | 2 | ALA4028818 | cell-based format | Scientific Literature | |
| 18. | ALA4029884 | A | Inhibition of recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 insect cells assessed as decrease in PGE2 release at 10 uM using arachidonic acid as substrate preincubated for 15 mins followed by arachidonic acid addition measured after 5 mins relative to control | Homo sapiens | 2 | ALA4028818 | cell-based format | Scientific Literature | |
| 19. | ALA4029885 | U | Selectivity ratio of IC50 for COX1 in human U937 cells to IC50 for recombinant human mPGES-1 expressed in CHO cells | Homo sapiens | 3 | ALA4028818 | cell-based format | Scientific Literature | |
| 20. | ALA4029886 | U | Selectivity ratio of IC50 for recombinant human N-terminal His-tagged COX2 expressed in baculovirus infected Sf21 insect cells to IC50 for recombinant human mPGES-1 expressed in CHO cells | Homo sapiens | 2 | ALA4028818 | cell-based format | Scientific Literature |
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