| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3993624 | B | Inhibition of recombinant human CA1 preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 2. | ALA3993625 | B | Inhibition of recombinant human CA2 preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 3. | ALA3993626 | B | Inhibition of recombinant human CA4 preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 4. | ALA3993627 | B | Inhibition of recombinant human CA7 preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 5. | ALA3993628 | B | Inhibition of recombinant human CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 6. | ALA3993629 | B | Inhibition of recombinant human CA12 preincubated for 15 mins by stopped-flow CO2 hydration assay | Homo sapiens | 17 | ALA3992527 | single protein format | Scientific Literature | |
| 7. | ALA3993630 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as weight tolerance on ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 15 mins post dose by analgesimetry (Rvb = 47.6 +/- 1.2 g) | Rattus norvegicus | 5 | ALA3992527 | organism-based format | Scientific Literature | |
| 8. | ALA3993631 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as weight tolerance on ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 30 mins post dose by analgesimetry (Rvb = 47.6 +/- 1.2 g) | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 9. | ALA3993632 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as weight tolerance on ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 45 mins post dose by analgesimetry (Rvb = 47.6 +/- 1.2 g) | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 10. | ALA3993633 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as increase in weight tolerance on ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 75 mins post dose by analgesimetry | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 11. | ALA3993636 | A | Effect on normal pain sensitivity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as change in contralateral paw withdrawal threshold at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured after 15 to 75 mins by analgesimetry | Rattus norvegicus | 9 | ALA3992527 | organism-based format | Scientific Literature | |
| 12. | ALA3993637 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as improvement in postural imbalance by measuring difference between weight burdened on contralateral and ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 30 mins post dose by incapacitance test (Rvb = 45.6 +/- 3.5 g) | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 13. | ALA3993638 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as improvement in postural imbalance by measuring difference between weight burdened on contralateral and ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 45 mins post dose by incapacitance test (Rvb = 45.6 +/- 3.5 g) | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 14. | ALA3993639 | F | Antihyperalgesic activity in complete Freund's adjuvant-induced Sprague-Dawley rat rheumatoid arthritis model assessed as improvement in postural imbalance by measuring difference between weight burdened on contralateral and ipsilateral paw at 10 mg/kg, po administered once on day 14 post complete Freund's adjuvant challenge measured at 60 mins post dose by incapacitance test | Rattus norvegicus | 1 | ALA3992527 | organism-based format | Scientific Literature | |
| 15. | ALA4403677 | A | Inhibition of COX1 in human platelet rich plasma in assessed as inhibition of ADP-induced platelet aggregation at 10 uM incubated for 5 mins by turbidimetry based Born's method relative to control | Homo sapiens | 11 | ALA4402543 | cell-free format | Scientific Literature | |
| 16. | ALA4403678 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring PGE2 level at 1 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA (Rvb = (2437 +/- 93.17 pg/mL) | Mus musculus | 12 | ALA4402543 | cell-based format | Scientific Literature | |
| 17. | ALA4403679 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring PGE2 level at 100 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA (Rvb = (2437 +/- 93.17 pg/mL) | Mus musculus | 11 | ALA4402543 | cell-based format | Scientific Literature | |
| 18. | ALA4403680 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring reduction in PGE2 level at 100 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA relative to control | Mus musculus | 2 | ALA4402543 | cell-based format | Scientific Literature | |
| 19. | ALA4403681 | B | Inhibition of COX2 in mouse RAW264.7 cells assessed as reduction in LPS-induced inflammation by measuring reduction in PGE2 level at 1 uM treated 1 hr after LPS stimulation and measured after 18 hrs by ELISA relative to control | Mus musculus | 1 | ALA4402543 | cell-based format | Scientific Literature | |
| 20. | ALA4403706 | F | Antihyperalgesic activity in Sprague-Dawley rat model of Complete freund's adjuvant-induced arthritis assessed as increase in pain threshold of ipsilateral paw at 10 mg/kg, po starting from day 14 after CFA injection and measured at 0 to 60 mins by paw pressure test | Rattus norvegicus | 1 | ALA4402543 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!