# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4046663 | Functional | Antiviral activity against HCV genotype 1b Con1 expressing NS3 protease infected in human Huh-7 cells assessed as reduction in viral RNA replication after 72 hrs by luciferase reporter gene assay | Hepacivirus hominis | 42 | ALA4043192 | cell-based format | Scientific Literature | |
2. | ALA4046680 | Unassigned | Selectivity index, ratio of CC50 for human Huh-7 cells to EC50 for HCV genotype 1b Con1 expressing NS3 protease | 39 | ALA4043192 | assay format | Scientific Literature | ||
3. | ALA4046681 | ADME | Dose normalized AUC (0 to 24 hrs) in mouse plasma assessed as 2'-C-MeU level at 10 mg/kg, po administered as single dose | Mus musculus | 39 | ALA4043192 | organism-based format | Scientific Literature | |
4. | ALA4046682 | ADME | Dose normalized AUC (0 to 24 hrs) in mouse liver assessed as 2'-C-MeUTP level at 10 mg/kg, po administered as single dose | Mus musculus | 39 | ALA4043192 | organism-based format | Scientific Literature |