# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4004648 | B | Induction of R-state stabilization of Hb betaGlu6Val mutant in sickle disease patient purified HbS/HbA mixture assessed as change from baseline of partial pressure of O2 at which HbS is 50% saturated with O2 at 30 uM preincubated for 45 mins followed by oxygenation for 10 mins and subsequent deoxygenation by hemoximetry relative to control | Homo sapiens | 42 | assay format | Scientific Literature | ||
2. | ALA4004649 | B | Induction of R-state stabilization of Hb betaGlu6Val mutant in sickle cell disease transfused human whole blood assessed as change from baseline of partial pressure of O2 at which HbS is 50% saturated with O2 at 1 mM preincubated for 45 mins followed by 20 mins oxygenation/deoxygenation cycle by hemoximetry relative to control | Homo sapiens | 22 | assay format | Scientific Literature | ||
3. | ALA4004650 | B | Induction of R-state stabilization of sickle cell Hb betaGlu6Val mutant purified from sickle cell patient assessed as inhibition of KH2PO4-induced polymerization by measuring change from baseline of delay time for onset of polymerization at 75 uM preincubated for 1 hr followed by deoxygenation for 90 mins at 4 degC and subsequent increase in temperature to 37 degC measured for 50 mins relative to control | Homo sapiens | 22 | assay format | Scientific Literature | ||
4. | ALA4004651 | A | Half life in Sprague-Dawley rat blood at 7.2 to 120 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 12 | organism-based format | Scientific Literature | ||
5. | ALA4004675 | A | Dose normalized AUC (0 to infinity) in Sprague-Dawley rat at 7.2 to 120 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 12 | organism-based format | Scientific Literature |