# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4047361 | Functional | Antiproliferative activity against human KG1 cells | Homo sapiens | 5 | ALA4043238 | cell-based format | Scientific Literature | |
2. | ALA4047362 | Binding | Inhibition of PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay | Homo sapiens | 34 | ALA4043238 | single protein format | Scientific Literature | |
3. | ALA4047363 | Binding | Inhibition of PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues by TR-FRET assay | Homo sapiens | 33 | ALA4043238 | single protein format | Scientific Literature | |
4. | ALA4047365 | Binding | Inhibition of PIM1 in human KG1 cells assessed as reduction in BAD phosphorylation | Homo sapiens | 4 | ALA4043238 | cell-based format | Scientific Literature | |
5. | ALA4047366 | ADME | Permeability from apical to basolateral side in human Caco2/TC7 cells at 5 uM | Homo sapiens | 5 | ALA4043238 | cell-based format | Scientific Literature | |
6. | ALA4047367 | Binding | Inhibition of human ERG by patch clamp assay | Homo sapiens | 4 | ALA4043238 | assay format | Scientific Literature | |
7. | ALA4047369 | Physicochemical | Thermodynamic solubility of the compound at pH 7.4 | 5 | ALA4043238 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4047380 | ADME | Stability in human liver microsomes | Homo sapiens | 2 | ALA4043238 | assay format | Scientific Literature | |
9. | ALA4047381 | ADME | Stability in rat liver microsomes | Rattus norvegicus | 2 | ALA4043238 | assay format | Scientific Literature | |
10. | ALA4047382 | ADME | Stability in mouse liver microsomes | Mus musculus | 2 | ALA4043238 | assay format | Scientific Literature | |
11. | ALA4047383 | ADME | Inhibition of CYP3A4 (unknown origin) using midazolam as substrate | Homo sapiens | 2 | ALA4043238 | single protein format | Scientific Literature | |
12. | ALA4047384 | ADME | Inhibition of CYP3A4 (unknown origin) using testosterone as substrate | Homo sapiens | 2 | ALA4043238 | single protein format | Scientific Literature | |
13. | ALA4047385 | ADME | AUC (0 to infinity) in rat at 3 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
14. | ALA4047386 | ADME | AUC (0 to infinity) in rat at 10 mg/kg, po administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
15. | ALA4047387 | ADME | Cmax in rat at 10 mg/kg, po administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
16. | ALA4047388 | ADME | Half life in rat at 3 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
17. | ALA4047389 | ADME | Clearance in rat at 3 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
18. | ALA4047390 | ADME | Volume of distribution at steady state in rat at 3 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
19. | ALA4047391 | Functional | In vivo inhibition of PIM1 in SCID mouse xenografted with human KG1 cells assessed as reduction in BAD phosphorylation at 25 mg/kg, po administered as single dose measured at 8 hrs relative to control | Mus musculus | 1 | ALA4043238 | organism-based format | Scientific Literature | |
20. | ALA4047392 | Functional | In vivo inhibition of PIM1 in SCID mouse xenografted with human KG1 cells assessed as reduction in BAD phosphorylation at 25 mg/kg, po administered as single dose measured at 24 hrs relative to control | Mus musculus | 1 | ALA4043238 | organism-based format | Scientific Literature |