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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4023942 A Total plasma clearance in Wistar Han rat at 1 mg/kg, iv measured up to 24 hrs post dose by LC-MS/MS analysis Rattus norvegicus 7 ALA4020835 organism-based format Scientific Literature 2. ALA4023943 P Dissociation constant, pKa of the compound by capillary electrophoresis 14 ALA4020835 small-molecule physicochemical format Scientific Literature 3. ALA4023944 A Drug excretion in Wistar Han rat urine assessed as compound recovered at 1 mg/kg, iv measured over 24 hrs by LC/MS analysis Rattus norvegicus 6 ALA4020835 organism-based format Scientific Literature 4. ALA4023945 A Drug excretion in cynomolgus monkey urine assessed as compound recovered at 1 mg/kg, iv measured over 24 hrs by LC/MS analysis Macaca fascicularis 2 ALA4020835 organism-based format Scientific Literature 5. ALA4023946 A Total renal clearance in Wistar Han rat blood at 1 mg/kg, iv measured up to 24 hrs post dose by LC-MS/MS analysis Rattus norvegicus 6 ALA4020835 organism-based format Scientific Literature 6. ALA4023953 A Unbound renal clearance in Wistar Han rat blood at 1 mg/kg, iv measured up to 24 hrs post dose by LC-MS/MS analysis Rattus norvegicus 6 ALA4020835 organism-based format Scientific Literature 7. ALA4023961 P Thermodynamic solubility of the compound in sodium phosphate buffer at pH 7.4 after 24 hrs by nitrogen detection method 2 ALA4020835 small-molecule physicochemical format Scientific Literature 8. ALA4023962 B Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assay Homo sapiens 14 ALA4020835 protein complex format Scientific Literature 9. ALA4023963 B Allosteric activation of human AMPK alpha1/beta1/gamma1 by TR-FRET assay relative to maximum activation of AMP Homo sapiens 14 ALA4020835 protein complex format Scientific Literature 10. ALA4023964 B Binding affinity to human BAP-tagged AMPK alpha1/beta1/gamma1 by SPR assay Homo sapiens 14 ALA4020835 protein complex format Scientific Literature 11. ALA4023965 P Lipophilicity, log D of compound at pH 7.4 by shake-flask method 14 ALA4020835 small-molecule physicochemical format Scientific Literature 12. ALA4023966 A Apparent permeability from apical to basolateral in RRCK cells after 1 hr by LC-MS analysis Canis lupus familiaris 14 ALA4020835 cell-based format Scientific Literature 13. ALA4023967 A Total intrinsic clearance in human hepatocytes assessed as per million cells at 1 uM after 4 hrs by LC-MS/MS analysis Homo sapiens 14 ALA4020835 cell-based format Scientific Literature 14. ALA4023968 A Substrate activity at human OAT3 expressed in HEK293 cells assessed as ratio of compound uptake in human OAT3 transfected HEK293 cells to uptake in vector-treated HEK293 cells at 1 uM after 3 mins by LC-MS analysis Homo sapiens 14 ALA4020835 cell-based format Scientific Literature 15. ALA4023969 A Substrate activity at rat OAT3 expressed in HEK293 cells assessed as ratio of compound uptake in rat OAT3 transfected HEK293 cells to uptake in vector-treated HEK293 cells at 1 uM after 3 mins by LC-MS analysis Rattus norvegicus 3 ALA4020835 cell-based format Scientific Literature 16. ALA4023970 A Substrate activity at human OAT1 expressed in HEK293 cells assessed as ratio of compound uptake in human OAT1 transfected HEK293 cells to uptake in vector-treated HEK293 cells at 1 uM after 3 mins by LC-MS analysis Homo sapiens 6 ALA4020835 cell-based format Scientific Literature 17. ALA4023971 A Plasma clearance in Wistar Han rat at 1 mg/kg, iv via bolus dose measured up to 24 hrs post dose by LC-MS/MS analysis Rattus norvegicus 2 ALA4020835 organism-based format Scientific Literature 18. ALA4023972 A Plasma clearance in cynomolgus monkey at 1 mg/kg, iv via bolus dose measured up to 24 hrs post dose by LC-MS/MS analysis Macaca fascicularis 2 ALA4020835 organism-based format Scientific Literature 19. ALA4023973 A Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv via bolus dose measured up to 24 hrs post dose by LC-MS/MS analysis Rattus norvegicus 2 ALA4020835 organism-based format Scientific Literature 20. ALA4023974 A Volume of distribution at steady state in cynomolgus monkey at 1 mg/kg, iv via bolus dose measured up to 24 hrs post dose by LC-MS/MS analysis Macaca fascicularis 2 ALA4020835 organism-based format Scientific Literature