# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4045304 | B | Inhibition of bovine brain tubulin polymerization | Bos taurus | 8 | ALA4043145 | assay format | Scientific Literature | |
2. | ALA4045305 | B | Inhibition of colchicine binding to bovine brain tubulin up to 25 uM by fluorescence based assay relative to control | Bos taurus | 1 | ALA4043145 | assay format | Scientific Literature | |
3. | ALA4045306 | B | Binding affinity to tubulin (unknown origin) by isothermal titration calorimetric analysis | Homo sapiens | 1 | ALA4043145 | assay format | Scientific Literature | |
4. | ALA4045379 | B | Binding affinity to tubulin (unknown origin) by CD spectroscopic method | Homo sapiens | 1 | ALA4043145 | assay format | Scientific Literature | |
5. | ALA4188620 | T | Toxicity in mouse | Mus musculus | 8 | ALA4184281 | organism-based format | Scientific Literature | |
6. | ALA4188621 | F | Antitumor activity against human SNU16 cells xenografted in nude BALB/c mouse assessed as tumor growth inhibition relative to control | Homo sapiens | 8 | ALA4184281 | cell-based format | Scientific Literature | |
7. | ALA4188622 | T | Toxicity in mouse administered as single po dose | Mus musculus | 3 | ALA4184281 | organism-based format | Scientific Literature | |
8. | ALA4188623 | F | Antitumor activity against human A2780 cells xenografted in nude BALB/c mouse assessed as tumor growth inhibition at 20 mg/kg, po qd measured up to 12 days post dose | Homo sapiens | 3 | ALA4184281 | organism-based format | Scientific Literature | |
9. | ALA4188624 | T | Toxicity in nude BALB/c mouse xenografted with human A2780 cells assessed as change in body weight at 20 mg/kg, po qd measured up to 12 days post dose | Mus musculus | 3 | ALA4184281 | organism-based format | Scientific Literature | |
10. | ALA4188625 | F | Antitumor activity against human A2780 cells xenografted in nude BALB/c mouse assessed as tumor growth inhibition at 15 mg/kg, po administered every other day measured up to 12 days post dose | Homo sapiens | 1 | ALA4184281 | organism-based format | Scientific Literature | |
11. | ALA4188626 | T | Toxicity in nude BALB/c mouse xenografted with human A2780 cells assessed as change in body weight at 15 mg/kg, po administered every other day measured up to 12 days post dose | Mus musculus | 1 | ALA4184281 | organism-based format | Scientific Literature | |
12. | ALA4188627 | A | Tmax in CD-1 mouse administered as single po dose by mass spectrometry | Mus musculus | 6 | ALA4184281 | organism-based format | Scientific Literature | |
13. | ALA4188629 | A | Unbound fraction in plasma (unknown origin) | Not specified | 4 | ALA4184281 | cell-free format | Scientific Literature | |
14. | ALA4188630 | A | Protein binding in plasma (unknown origin) | Not specified | 4 | ALA4184281 | cell-free format | Scientific Literature | |
15. | ALA4188631 | A | Drug recovery in plasma (unknown origin) | Not specified | 4 | ALA4184281 | cell-free format | Scientific Literature | |
16. | ALA4188632 | A | Stability in human plasma assessed as parent compound remaining after 75 mins relative to initial time | Homo sapiens | 4 | ALA4184281 | cell-free format | Scientific Literature | |
17. | ALA4188633 | A | Stability in human plasma assessed as parent compound remaining after 2 hrs relative to initial time | Homo sapiens | 4 | ALA4184281 | cell-free format | Scientific Literature | |
18. | ALA4188634 | A | Stability in human plasma assessed as parent compound remaining after 4 hrs relative to initial time | Homo sapiens | 4 | ALA4184281 | cell-free format | Scientific Literature | |
19. | ALA4188635 | A | Stability in human plasma assessed as parent compound remaining after 8 hrs relative to initial time | Homo sapiens | 4 | ALA4184281 | cell-free format | Scientific Literature | |
20. | ALA4188636 | A | Stability in human plasma assessed as parent compound remaining after 24 hrs relative to initial time | Homo sapiens | 4 | ALA4184281 | cell-free format | Scientific Literature |