| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4020310 | A | Dose normalized AUC (0 to infinity) in C57BL/6 mouse at 30 mg/kg, iv administered as single dose measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 2. | ALA4020311 | B | Inhibition of Mycobacterium tuberculosis H37Rv N-terminal 6His-tagged LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Mycobacterium tuberculosis H37Rv | 44 | assay format | Scientific Literature | ||
| 3. | ALA4020312 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv | Mycobacterium tuberculosis | 44 | assay format | Scientific Literature | ||
| 4. | ALA4020313 | A | Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 5. | ALA4020314 | T | Selectivity index, ratio of EC50 for inhibition of cytoplasmic LeuRS in HepG2 cells assessed as reduction in protein synthesis to MIC for Mycobacterium tuberculosis H37Rv | 8 | cell-based format | Scientific Literature | |||
| 6. | ALA4020315 | A | Inhibition of human N-terminal 6His-tagged mitochondrial LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to Escherichia coli tRNA after 20 mins by liquid scintillation counting analysis | Homo sapiens | 8 | assay format | Scientific Literature | ||
| 7. | ALA4020316 | A | Inhibition of cytoplasmic LeuRS in human HepG2 cells assessed as reduction in protein synthesis preincubated for 48 hrs followed by L-[14C]leucine addition measured after 3 hrs by liquid scintillation counting analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 8. | ALA4020317 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by CellTiter-Glo assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 9. | ALA4020333 | A | Cmax in C57BL/6 mouse at 30 mg/kg administered as single dose via oral gavage measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA4020334 | A | Tmax in C57BL/6 mouse at 30 mg/kg administered as single dose via oral gavage measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4020335 | A | AUC (0 to 24 hrs) in C57BL/6 mouse at 30 mg/kg administered as single dose via oral gavage by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4020336 | A | Dose normalized AUC (0 to 24 hrs) in C57BL/6 mouse at 30 mg/kg administered as single dose via oral gavage by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4020337 | A | Volume of distribution at steady state in C57BL/6 mouse at 30 mg/kg, iv administered as single dose measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4020338 | A | Oral bioavailability in C57BL/6 mouse at 30 mg/kg administered as single dose via gavage measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4020339 | A | Clearance in C57BL/6 mouse at 30 mg/kg, iv administered as single dose measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4020340 | A | Half life in C57BL/6 mouse at 30 mg/kg, iv administered as single dose measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4020341 | A | AUC (0 to infinity) in C57BL/6 mouse at 30 mg/kg, iv administered as single dose measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4020362 | F | Antimicrobial activity against Mycobacterium tuberculosis H37Rv infected in C57BL/6J mouse assessed as 2 log reduction in bacterial load in lungs administered qd for 8 consecutive days starting on day 1 post infection measured 24 hrs post last dose | Mycobacterium tuberculosis | 4 | assay format | Scientific Literature |
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