# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4048554 | B | Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 0.5 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay | Mus musculus | 46 | cell-based format | Scientific Literature | ||
2. | ALA4048556 | B | Inhibition of RIPK1 in mouse L929sA cells transfected with human Fas assessed as inhibition in TNF-induced necroptosis pretreated for 24 hrs followed by TNF and zVAD.fmk addition measured after 3 hrs by Hoechst 33342/propidium iodide staining-based assay | Mus musculus | 46 | cell-based format | Scientific Literature | ||
3. | ALA4048557 | A | Inhibition of Aurk mouse L929sA cells transfected with human Fas assessed as reduction in cell growth after 24 hrs in presence of TNF by Hoechst 33342 staining-based microscopic assay | Mus musculus | 46 | assay format | Scientific Literature | ||
4. | ALA4048558 | A | Inhibition of Aurk mouse L929sA cells transfected with human Fas assessed as increase in nuclear area after 24 hrs in presence of TNF by Hoechst 33342 staining-based microscopic assay | Mus musculus | 46 | assay format | Scientific Literature | ||
5. | ALA4048561 | A | Inhibition of Aurk in mouse L929sA cells transfected with human Fas assessed as reduction in cell growth at 3 uM after 24 hrs in presence of TNF by Hoechst 33342 staining-based microscopic assay relative to control | Mus musculus | 35 | cell-based format | Scientific Literature | ||
6. | ALA4048562 | A | Inhibition of Aurk in mouse L929sA cells transfected with human Fas assessed as increase in nuclear area at 3 uM after 24 hrs in presence of TNF by Hoechst 33342 staining-based microscopic assay relative to control | Mus musculus | 40 | cell-based format | Scientific Literature | ||
7. | ALA4048563 | A | Inhibition of human recombinant AurKA after 4 hrs by ADP-Glo assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
8. | ALA4048564 | A | Inhibition of human recombinant AurKB after 4 hrs by ADP-Glo assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
9. | ALA4048565 | B | Inhibition of human recombinant RIPK1 after 4 hrs by ADP-Glo assay | Homo sapiens | 6 | single protein format | Scientific Literature | ||
10. | ALA4048566 | F | Protection against TNF-induced hypothermia in TNF-induced SIRS C57BL/6J mouse model at 50 mg/kg administered via oral gavage treated 1.5 hrs prior to TNF challenge by thermometric analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
11. | ALA4048567 | F | Protection against TNF-induced death in TNF-induced SIRS C57BL/6J mouse model at 50 mg/kg administered via oral gavage treated 1.5 hrs prior to TNF challenge by thermometric analysis | Mus musculus | 5 | organism-based format | Scientific Literature |