# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA5151843 | Binding | Binding affinity to WDR5 (unknown origin) fluorescence polarization assay | Homo sapiens | 8 | ALA5150001 | single protein format | Scientific Literature | |
2. | ALA5151844 | Binding | Inhibition of MLL1/WDR5/RbBP5/ASH2L complex (unknown origin) histamine methyltransferase activity assessed as inhibition of H3K4 methylation preincubated with WDR5/RbBP5/ASH2L preassembled complex for 2 to 5 mins followed enzyme and substrate addition and measured after 30 mins using H310mer peptide as substrate in presence of H3-SAM by scintillation counter analysis | Homo sapiens | 2 | ALA5150001 | assay format | Scientific Literature | |
3. | ALA5151845 | Functional | Antitumor activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition incubated for 4 days by Cell-TiterGlo assay | Homo sapiens | 1 | ALA5150001 | cell-based format | Scientific Literature | |
4. | ALA5151846 | Functional | Antitumor activity against human MOLM-13 cells harboring MLL-AF9 fusion protein assessed as cell growth inhibition incubated for 4 days by Cell-TiterGlo assay | Homo sapiens | 1 | ALA5150001 | cell-based format | Scientific Literature | |
5. | ALA5151847 | Functional | Antitumor activity against human KOPN-8 cells harboring MLL-ENL fusion protein assessed as cell growth inhibition incubated for 4 days by Cell-TiterGlo assay | Homo sapiens | 1 | ALA5150001 | cell-based format | Scientific Literature | |
6. | ALA5151848 | ADME | Stability in human liver microsomes assessed as half life | Homo sapiens | 1 | ALA5150001 | microsome format | Scientific Literature |