# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4124536 | B | Inhibition of APN in porcine kidney microsomes using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after 30 mins | Sus scrofa | 42 | ALA4118239 | microsome format | Scientific Literature | |
2. | ALA4124537 | B | Potency index, ratio of bestatin IC50 to compound IC50 for APN in porcine kidney microsomes | Sus scrofa | 1 | ALA4118239 | microsome format | Scientific Literature | |
3. | ALA4124538 | B | Inhibition of APN in human ES2 cells using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after 1 hr | Homo sapiens | 7 | ALA4118239 | cell-based format | Scientific Literature | |
4. | ALA4124539 | B | Inhibition of APN in human PLC/PRF/5 cells using L-Leu-pnitroanilide as substrate pretreated for 5 mins followed by substrate addition measured after 1 hr | Homo sapiens | 7 | ALA4118239 | cell-based format | Scientific Literature | |
5. | ALA4124540 | F | Antiproliferative activity against human U937 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
6. | ALA4124541 | F | Antiproliferative activity against human HCT116 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
7. | ALA4124542 | F | Antiproliferative activity against human A549 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
8. | ALA4124543 | F | Antiproliferative activity against human ES2 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
9. | ALA4124544 | F | Antiproliferative activity against human PLC cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
10. | ALA4124545 | F | Antiproliferative activity against human K562 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
11. | ALA4124546 | F | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
12. | ALA4124547 | F | Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay | Homo sapiens | 3 | ALA4118239 | cell-based format | Scientific Literature | |
13. | ALA4124548 | F | Antiangiogenic activity in HUVEC assessed as inhibition of capillary-like tube formation after 4 hrs by matrigel-based assay | Homo sapiens | 1 | ALA4118239 | cell-based format | Scientific Literature | |
14. | ALA4124550 | F | Antiangiogenic activity in Sprague-Dawley rat thoracic aorta ring assessed as reduction in micro-vessel growth supplemented with fresh medium containing compound every 3 for 9 days measured on day 9 by matrigel-based inverted microscopic analysis | Rattus norvegicus | 1 | ALA4118239 | tissue-based format | Scientific Literature | |
15. | ALA4124552 | F | Anti-metastatic activity against mouse H22 cells implanted in Kunming mouse assessed as reduction in number of metastatic nodes at 60 mg/kg, ip administered once daily for 12 days measured on day 13 by bouin's staining based assay relative to control | Mus musculus | 2 | ALA4118239 | organism-based format | Scientific Literature | |
16. | ALA4124553 | T | Toxicity in Kunming mouse implanted with mouse H22 cells assessed as body weight loss at 60 mg/kg, ip administered once daily for 12 days measured every 2 days during compound dosing | Mus musculus | 1 | ALA4118239 | organism-based format | Scientific Literature | |
17. | ALA4124554 | T | Hepatotoxicity in Kunming mouse implanted with mouse H22 cells at 60 mg/kg, ip administered once daily for 12 days | Mus musculus | 1 | ALA4118239 | organism-based format | Scientific Literature | |
18. | ALA4124555 | T | Toxicity in Kunming mouse implanted with mouse H22 cells assessed as effect on spleen at 60 mg/kg, ip administered once daily for 12 days | Mus musculus | 1 | ALA4118239 | organism-based format | Scientific Literature |