# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4124653 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA4124654 | B | Induction of CRBN ubiquitin ligase-mediated HDAC1 degradation in human MCF7 cells assessed as decrease in HDAC1 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
3. | ALA4124655 | B | Induction of CRBN ubiquitin ligase-mediated HDAC2 degradation in human MCF7 cells assessed as decrease in HDAC2 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
4. | ALA4124656 | B | Induction of CRBN ubiquitin ligase-mediated HDAC4 degradation in human MCF7 cells assessed as decrease in HDAC4 levels at 5 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
5. | ALA4124657 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4124662 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 1.1 to 10 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
7. | ALA4124663 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM after 2 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4124664 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM after 2 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4124665 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with proteosome-inhibitor MG132 followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
10. | ALA4124666 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with CRBN ligand pomalidomide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
11. | ALA4124667 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM preincubated for 1 hr with proteosome-inhibitor MG132 followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4124668 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM at 2 uM preincubated for 1 hr with CRBN ligand pomalidomide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4124669 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with 1 uM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4124670 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as decrease in HDAC6 levels at 2 uM preincubated for 1 hr with 100 nM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4124671 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MCF7 cells assessed as increase in acetylated alpha-tubulin levels at 2 uM preincubated for 1 hr with 100 nM pan-HDAC inhibitor N-hydroxy-8-(2-(4-methoxybenzylidene)hydrazinyl)-8-oxooctanamide followed by compound addition for 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4124672 | B | Induction of CRBN ubiquitin ligase-mediated HDAC1 degradation in human MCF7 cells assessed as increase in acetylated H3 levels at 2 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4124673 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MM1S cells assessed as decrease in HDAC6 levels at =>80 nM after 6 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4124674 | B | Induction of CRBN ubiquitin ligase-mediated HDAC6 degradation in human MM1S cells assessed as increase in acetylated alpha-tubulin levels at =>80 nM after 6 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4124675 | B | Induction of CRBN ubiquitin ligase-mediated HDAC2 degradation in human MCF7 cells assessed as increase in acetylated H3 levels at 2 uM after 12 hrs by immunoblotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4312360 | B | Protac activity at CRBN/HDAC6 in human MM1S cells assessed as HDAC6 degradation at 100 nM measured after 6 hrs by ELISA relative to control | Homo sapiens | 21 | cell-based format | Scientific Literature |