# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4121910 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM at 1 uM after 4 days by TRAP staining method relative to control | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
2. | ALA4121911 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM at 5 to 10 uM after 4 days by TRAP staining method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
3. | ALA4121912 | ADME | Growth inhibition of ICR mouse BMDM up to 10 uM after 3 days by MTT assay | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
4. | ALA4121913 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as downregulation of Acp5 mRNA expression at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
5. | ALA4121914 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as downregulation of Ctsk mRNA expression at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
6. | ALA4121915 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as downregulation of Dcstamp mRNA expression at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
7. | ALA4121916 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as downregulation of Nfatc1 mRNA expression at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
8. | ALA4121917 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as downregulation of Nfatc1 expression at 5 uM after 3 days by Western blot method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
9. | ALA4121918 | Functional | Inhibition of M-CSF/RANKL-induced osteoclast differentiation in ICR mouse BMDM assessed as decrease in number of cells with nuclear Nfatc1 at 5 uM by rhodamine-conjugated phalloidin/DAPI staining-based immunofluorescence method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
10. | ALA4121919 | Functional | Effect on bone-resorbing function of osteoclast derived from M-CSF/RANKL-induced ICR mouse BMDM assessed as change in size of resorption pit area at 5 uM after 2 days by hematoxylin staining-based assay | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
11. | ALA4121920 | Binding | Inhibition of RANKL-induced p38 phosphorylation in ICR mouse BMDM at 5 uM preincubated for 1 hr followed by RANKL stimulation measured after 5 to 30 mins by Western blot method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
12. | ALA4121921 | Binding | Inhibition of RANKL-induced ERK phosphorylation in ICR mouse BMDM at 5 uM preincubated for 1 hr followed by RANKL stimulation measured after 5 to 30 mins by Western blot method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
13. | ALA4121922 | Binding | Inhibition of RANKL-induced AKT phosphorylation in ICR mouse BMDM at 5 uM preincubated for 1 hr followed by RANKL stimulation measured after 30 mins by Western blot method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
14. | ALA4121923 | Functional | Inhibition of RANKL-mediated decrease in Irf8 mRNA expression in ICR mouse BMDM at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
15. | ALA4121924 | Functional | Inhibition of RANKL-mediated decrease in Bcl6 mRNA expression in ICR mouse BMDM at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature | |
16. | ALA4121925 | Functional | Inhibition of RANKL-mediated decrease in Mafb mRNA expression in ICR mouse BMDM at 5 uM by qRT-PCR method | Mus musculus | 1 | ALA4118133 | cell-based format | Scientific Literature |