| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4122092 | F | Cognition enhancing effect in albino Swiss CD-1 mouse assessed as reversal of scopolamine-induced amnesia at 20 to 30 mg/kg, ip treated 30 mins prior to acquisition trial followed by scopolamine challenge immediately after acquisition trial by passive avoidance test (Rvb = 39.31 +/- 4.01 secs) | Mus musculus | 2 | ALA4118139 | organism-based format | Scientific Literature | |
| 2. | ALA4122093 | B | Displacement of [3H]N-alpha-methylhistamine from full length human H3 receptor expressed in HEK293 cell membranes after 90 mins | Homo sapiens | 16 | ALA4118139 | cell-based format | Scientific Literature | |
| 3. | ALA4122094 | F | Antagonist activity at human H3 receptor expressed in HEK293 cells assessed as inhibition of RAMH-induced reduction of forskolin-stimulated cAMP accumulation after 30 mins by Ulight-based TR-FRET assay | Homo sapiens | 2 | ALA4118139 | cell-based format | Scientific Literature | |
| 4. | ALA4122095 | F | In vivo antagonist activity at H3 receptor in RAMH-induced dipsogenic ip dosed Wistar (Krf:(WI) WU) rat model assessed as inhibition of RAMH-water intake administered 30 mins prior to RAMH induction | Rattus norvegicus | 2 | ALA4118139 | organism-based format | Scientific Literature | |
| 5. | ALA4122097 | F | Agonist activity at histamine H1 receptor in guinea-pig ileum assessed as induction of contractions at 1 to 3 uM after 15 mins | Cavia porcellus | 2 | ALA4118139 | assay format | Scientific Literature | |
| 6. | ALA4122098 | F | Agonist activity at muscarinic M3 receptor in guinea-pig ileum assessed as induction of contractions at 1 to 3 uM after 15 mins | Cavia porcellus | 2 | ALA4118139 | assay format | Scientific Literature | |
| 7. | ALA4122099 | F | Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins | Cavia porcellus | 2 | ALA4118139 | assay format | Scientific Literature | |
| 8. | ALA4122100 | F | Antagonist activity at muscarinic M3 receptor in guinea-pig ileum assessed as inhibition of carbachol-induced contractions after 15 mins | Cavia porcellus | 2 | ALA4118139 | assay format | Scientific Literature | |
| 9. | ALA4122107 | F | Anticonvulsant activity in Sprague-Dawley rat assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.5 hrs | Rattus norvegicus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 10. | ALA4122108 | F | Anticonvulsant activity in Sprague-Dawley rat assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 1 hr | Rattus norvegicus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 11. | ALA4122109 | F | Anticonvulsant activity in Sprague-Dawley rat assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, ip after 0.25 hrs | Rattus norvegicus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 12. | ALA4122110 | F | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 50 mg/kg, ip after 0.25 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 13. | ALA4122111 | F | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 50 mg/kg, ip after 0.5 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 14. | ALA4122112 | F | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 50 mg/kg, ip after 1 hr | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 15. | ALA4122113 | F | Anticonvulsant activity in albino CF-1 mouse assessed as protection against maximal electroshock-induced seizures at 50 mg/kg, ip after 4 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 16. | ALA4122114 | T | Neurotoxicity in albino CF-1 mouse assessed as increase in subcutaneous pentylenetetrazole-induced continuous seizures at 50 mg/kg, ip measured after 0.25 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 17. | ALA4122115 | T | Neurotoxicity in albino CF-1 mouse assessed as increase in subcutaneous pentylenetetrazole-induced continuous seizures at 50 mg/kg, ip measured after 0.5 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 18. | ALA4122116 | T | Neurotoxicity in albino CF-1 mouse assessed as increase in subcutaneous pentylenetetrazole-induced continuous seizures at 50 mg/kg, ip measured after 1 hr | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 19. | ALA4122117 | T | Neurotoxicity in albino CF-1 mouse assessed as increase in subcutaneous pentylenetetrazole-induced continuous seizures at 50 mg/kg, ip measured after 2 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature | |
| 20. | ALA4122118 | F | Anticonvulsant activity in albino CF-1 mouse assessed as protection against subcutaneous pentylenetetrazole-induced seizures at 50 mg/kg, ip measured after 4 hrs | Mus musculus | 1 | ALA4118139 | organism-based format | Scientific Literature |
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