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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4124800 F Agonist activity at human GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Homo sapiens 16 ALA4118251 cell-based format Scientific Literature 2. ALA4124801 F Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Homo sapiens 16 ALA4118251 cell-based format Scientific Literature 3. ALA4124802 F Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Homo sapiens 16 ALA4118251 cell-based format Scientific Literature 4. ALA4124803 B Selectivity ratio of EC50 for human glucagon receptor expressed in HEK293 cells to EC50 for human GLP1R expressed in HEK293 cells Homo sapiens 3 ALA4118251 cell-based format Scientific Literature 5. ALA4124806 P Solubility in pH 4.5 acetate buffer at 10 mg/ml after 2 hrs by UPLC-UV analysis 2 ALA4118251 small-molecule physicochemical format Scientific Literature 6. ALA4124807 P Solubility in pH 4.5 acetate buffer at 10 mg/ml after 2 hrs in presence of 0.5% phenol by UPLC-UV analysis 2 ALA4118251 small-molecule physicochemical format Scientific Literature 7. ALA4124808 P Solubility in pH 4.5 phosphate buffer at 10 mg/ml after 2 hrs by UPLC-UV analysis 2 ALA4118251 small-molecule physicochemical format Scientific Literature 8. ALA4124809 P Solubility in pH 4.5 phosphate buffer at 10 mg/ml after 2 hrs in presence of 0.5% phenol by UPLC-UV analysis 2 ALA4118251 small-molecule physicochemical format Scientific Literature 9. ALA4124810 B Agonist activity at monkey GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Macaca mulatta 4 ALA4118251 cell-based format Scientific Literature 10. ALA4124811 B Agonist activity at monkey glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Macaca mulatta 4 ALA4118251 cell-based format Scientific Literature 11. ALA4124812 B Agonist activity at monkey GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay Macaca mulatta 4 ALA4118251 cell-based format Scientific Literature 12. ALA4124813 B Ratio of EC50 for monkey glucagon receptor expressed in HEK293 cells to EC50 for human glucagon receptor expressed in HEK293 cells 2 ALA4118251 cell-based format Scientific Literature 13. ALA4124815 F Antiobesity activity in diet-induced obesity cynomolgus monkey model assessed as reduction in body weight at 1.5 ug/kg on day 1 to 3, 3 ug/kg on day 4 to 6, 4.5 ug/kg on day 7 to 9, 6 ug/kg from day 10 to 17 and 8 ug/kg on day 18 to 42 administered sc once daily measured every 3 to 4 days during compound dosing relative to control Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 14. ALA4124816 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured immediately post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 15. ALA4124817 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 1 hr post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 16. ALA4124818 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 2 hrs post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 17. ALA4124819 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 4 hrs post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 18. ALA4124820 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 8 hrs post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 19. ALA4124821 A Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 22 hrs post dose on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature 20. ALA4124822 A AUC (0 to 22 hrs) in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks on day 43 by LC-MS analysis Macaca fascicularis 1 ALA4118251 organism-based format Scientific Literature