| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4124800 | F | Agonist activity at human GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 2. | ALA4124801 | F | Agonist activity at human glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA4124802 | F | Agonist activity at human GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Homo sapiens | 16 | cell-based format | Scientific Literature | ||
| 4. | ALA4124803 | B | Selectivity ratio of EC50 for human glucagon receptor expressed in HEK293 cells to EC50 for human GLP1R expressed in HEK293 cells | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4124806 | P | Solubility in pH 4.5 acetate buffer at 10 mg/ml after 2 hrs by UPLC-UV analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 6. | ALA4124807 | P | Solubility in pH 4.5 acetate buffer at 10 mg/ml after 2 hrs in presence of 0.5% phenol by UPLC-UV analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 7. | ALA4124808 | P | Solubility in pH 4.5 phosphate buffer at 10 mg/ml after 2 hrs by UPLC-UV analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4124809 | P | Solubility in pH 4.5 phosphate buffer at 10 mg/ml after 2 hrs in presence of 0.5% phenol by UPLC-UV analysis | 2 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4124810 | B | Agonist activity at monkey GLP1R expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Macaca mulatta | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4124811 | B | Agonist activity at monkey glucagon receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Macaca mulatta | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4124812 | B | Agonist activity at monkey GIP receptor expressed in HEK293 cells assessed as cAMP accumulation after 30 mins by HTRF assay | Macaca mulatta | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4124813 | B | Ratio of EC50 for monkey glucagon receptor expressed in HEK293 cells to EC50 for human glucagon receptor expressed in HEK293 cells | 2 | cell-based format | Scientific Literature | |||
| 13. | ALA4124815 | F | Antiobesity activity in diet-induced obesity cynomolgus monkey model assessed as reduction in body weight at 1.5 ug/kg on day 1 to 3, 3 ug/kg on day 4 to 6, 4.5 ug/kg on day 7 to 9, 6 ug/kg from day 10 to 17 and 8 ug/kg on day 18 to 42 administered sc once daily measured every 3 to 4 days during compound dosing relative to control | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4124816 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured immediately post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4124817 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 1 hr post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4124818 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 2 hrs post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4124819 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 4 hrs post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4124820 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 8 hrs post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4124821 | A | Plasma concentration in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks measured 22 hrs post dose on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4124822 | A | AUC (0 to 22 hrs) in diet-induced obesity cynomolgus monkey model at 8 ug/kg, sc for 6 weeks on day 43 by LC-MS analysis | Macaca fascicularis | 1 | organism-based format | Scientific Literature |
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