| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4119717 | B | Inhibition of hedgehog signaling pathway in mouse NIH/3T3 Light2 cells by Gli-luciferase reporter gene assay | Mus musculus | 25 | cell-based format | Scientific Literature | ||
| 2. | ALA4119718 | F | Antiproliferative activity against Ptch+/- and p53-/- mouse medulloblastoma cells after 36 hrs by Brdu incorporation assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 3. | ALA4119719 | B | Potency index, ratio of vismodegib IC50 to compound IC50 for hedgehog signaling pathway in mouse NIH/3T3 Light2 cells | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4119720 | F | Antitumor activity against Ptch+/- and p53-/- mouse medulloblastoma cells allografted in athymic nude mouse assessed as tumor growth inhibition at 50 mg/kg, po bid administered daily via gavage for 13 days | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 5. | ALA4119721 | F | Antitumor activity against Ptch+/- and p53-/- mouse medulloblastoma cells allografted in athymic nude mouse assessed as tumor growth inhibition at 100 mg/kg, po qd administered daily via gavage for 13 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4119722 | A | AUC (0 to infinity) in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4119723 | A | Clearance in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4119724 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4119725 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4119726 | A | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4119727 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4119728 | A | Tmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4119729 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered as single dose | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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