| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4123115 | B | Inhibition of endoplasmic reticulum calcium channel in human MDA-MB-231 cells assessed as reduction in endoplasmic reticulum intracellular calcium release at 100 uM pretreated for 15 mins followed by SERCA inhibitor CPA addition measured after 700 secs by PBX dye based FLIPR assay relative to control | Homo sapiens | 69 | cell-based format | Scientific Literature | ||
| 2. | ALA4123117 | B | Inhibition of BAPTA-induced Orai1-medited store operated calcium entry in human MDA-MB-231 cells at 100 uM pretreated for 15 mins followed by BAPTA addition by PBX dye based FLIPR assay relative to control | Homo sapiens | 44 | cell-based format | Scientific Literature | ||
| 3. | ALA4123118 | B | Inhibition of BAPTA-induced Orai1-medited store operated calcium entry in human MDA-MB-231 cells at 10 uM pretreated for 15 mins followed by BAPTA addition by PBX dye based FLIPR assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4123119 | B | Inhibition of rat TRPV1 expressed in HEK293 cells assessed as reduction in capsaicin-induced calcium flux up to 100 uM pretreated for 300 secs followed by capsaicin addition by calcium 4-dye based FLIPR assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4123120 | B | Inhibition of rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux up to 100 uM pretreated for 300 secs followed by menthol addition by calcium 4-dye based FLIPR assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4123121 | B | Inhibition of Cav2.2 in human SH-SY5Y cells assessed as reduction in KCl/CaCl2-induced calcium flux up to 100 uM pretreated for 300 secs followed by KCl/CaCl2 addition measured in presence of nifedipine by calcium 4-dye based FLIPR assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4123122 | B | Inhibition of human ERG at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4123123 | A | Half life in human liver microsomes | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 9. | ALA4123124 | A | Half life in mouse liver microsomes | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 10. | ALA4123125 | P | Solubility of the compound in alpha minimum essential medium | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 11. | ALA4123126 | A | Stability of the compound in M1/M0 H2O | 1 | assay format | Scientific Literature | |||
| 12. | ALA4123127 | P | Lipophilicity, log P of the compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 13. | ALA4123132 | B | Inhibition of Cav1.2 (unknown origin) up to 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 14. | ALA4123133 | B | Inhibition of Cav1.3 (unknown origin) up to 100 uM | Homo sapiens | 1 | single protein format | Scientific Literature |
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