| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4122329 | Binding | Displacement of [3H]8-prazosin from adrenergic alpha1 receptor in Wistar rat cortex at 10'-5 M incubated for 30 mins by microbeta liquid scintillation counting analysis | Rattus norvegicus | 3 | ALA4118148 | assay format | Scientific Literature | |
| 2. | ALA4122330 | Binding | Displacement of [3H]-clonidine from adrenergic alpha2 receptor in Wistar rat cortex at 10'-5 M incubated for 25 mins by microbeta liquid scintillation counting analysis | Rattus norvegicus | 8 | ALA4118148 | assay format | Scientific Literature | |
| 3. | ALA4122331 | Binding | Displacement of [3H]-CGP-12177 from adrenergic beta1 receptor in Wistar rat cortex incubated for 60 mins by microbeta liquid scintillation counting analysis | Rattus norvegicus | 8 | ALA4118148 | assay format | Scientific Literature | |
| 4. | ALA4122334 | Functional | Antagonist activity at adrenergic beta2 receptor in isolated guinea pig trachea assessed as inhibition of isoprenaline-induced bronchodilation incubated for 20 mins | Cavia porcellus | 7 | ALA4118148 | assay format | Scientific Literature | |
| 5. | ALA4122336 | Functional | In vivo inhibition of beta adrenoceptor in Wistar rat assessed as reduction in isoprenaline-induced tachycardia at 5 mg/kg, iv administered as single dose 10 mins prior to isoprenaline injection | Rattus norvegicus | 5 | ALA4118148 | organism-based format | Scientific Literature | |
| 6. | ALA4122345 | Functional | Hypotensive activity in normotensive Wistar rat assessed as systolic blood pressure at 5 mg/kg, iv measured after 5 mins (Rvb = 119.2 to 148.6 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 7. | ALA4122346 | Functional | Hypotensive activity in normotensive Wistar rat assessed as diastolic blood pressure at 5 mg/kg, iv measured after 5 mins (Rvb = 86.5 to 119.4 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 8. | ALA4122353 | Functional | Hypotensive activity in normotensive Wistar rat assessed as systolic blood pressure at 5 mg/kg, iv measured after 10 mins (Rvb = 119.2 to 148.6 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 9. | ALA4122354 | Functional | Hypotensive activity in normotensive Wistar rat assessed as diastolic blood pressure at 5 mg/kg, iv measured after 10 mins (Rvb = 86.5 to 119.4 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 10. | ALA4122361 | Functional | Hypotensive activity in normotensive Wistar rat assessed as systolic blood pressure at 5 mg/kg, iv measured after 20 mins (Rvb = 119.2 to 148.6 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 11. | ALA4122362 | Functional | Hypotensive activity in normotensive Wistar rat assessed as diastolic blood pressure at 5 mg/kg, iv measured after 20 mins (Rvb = 86.5 to 119.4 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 12. | ALA4122369 | Functional | Hypotensive activity in normotensive Wistar rat assessed as systolic blood pressure at 5 mg/kg, iv measured after 30 mins (Rvb = 119.2 to 148.6 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 13. | ALA4122370 | Functional | Hypotensive activity in normotensive Wistar rat assessed as diastolic blood pressure at 5 mg/kg, iv measured after 30 mins (Rvb = 86.5 to 119.4 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 14. | ALA4122377 | Functional | Hypotensive activity in normotensive Wistar rat assessed as systolic blood pressure at 5 mg/kg, iv measured after 60 mins (Rvb = 119.2 to 148.6 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 15. | ALA4122378 | Functional | Hypotensive activity in normotensive Wistar rat assessed as diastolic blood pressure at 5 mg/kg, iv measured after 60 mins (Rvb = 86.5 to 119.4 mmHg) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 16. | ALA4122389 | Functional | Hypotensive activity in normotensive Wistar rat assessed as reduction in systolic blood pressure administered iv measured after 60 mins | Rattus norvegicus | 2 | ALA4118148 | organism-based format | Scientific Literature | |
| 17. | ALA4122390 | Toxicity | Cardiotoxicity in Wistar rat assessed as effect on heart rate at 5 mg/kg, iv measured after 1 min (Rvb = 323 to 374.5 bpm) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 18. | ALA4122391 | Toxicity | Cardiotoxicity in Wistar rat assessed as effect on PQ interval time at 5 mg/kg, iv measured after 1 min (Rvb = 52 to 57 ms) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 19. | ALA4122392 | Toxicity | Cardiotoxicity in Wistar rat assessed as effect on QRS interval time at 5 mg/kg, iv measured after 1 min (Rvb = 16.7 to 20.7 ms) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature | |
| 20. | ALA4122393 | Toxicity | Cardiotoxicity in Wistar rat assessed as effect on QT interval time at 5 mg/kg, iv measured after 1 min (Rvb = 57.7 to 61 ms) | Rattus norvegicus | 7 | ALA4118148 | organism-based format | Scientific Literature |
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