| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4124177 | B | Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in baculovirus expression system assessed as reduction in polypeptide substrate phosphorylation in presence of ATP by ELISA | Homo sapiens | 30 | assay format | Scientific Literature | ||
| 2. | ALA4124181 | B | Inhibition of human JAK1 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 3. | ALA4124183 | A | Inhibition of human JAK2 using poly[Glu:Tyr] (4:1) as substrate in presence of 10 uM [gamma33P]ATP by radiometric method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 4. | ALA4124185 | B | Inhibition of human JAK3 using GEEEEYFELVKKKK as substrate in presence of 10 uM [gamma33P]ATP by radiometric method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 5. | ALA4124187 | B | Inhibition of human TYK2 using KKSRGDYMTMQIG as substrate in presence of 10 uM [gamma33P]ATP by radiometric method | Homo sapiens | 9 | single protein format | Scientific Literature | ||
| 6. | ALA4124189 | B | Selectivity ratio of IC50 for human JAK1 in presence of 10 uM ATP to IC50 for human JAK3 in presence of 10 uM ATP | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 7. | ALA4124190 | B | Selectivity ratio of IC50 for human JAK2 in presence of 10 uM ATP to IC50 for human JAK3 in presence of 10 uM ATP | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 8. | ALA4124191 | B | Selectivity ratio of IC50 for human TYK2 in presence of 10 uM ATP to IC50 for human JAK3 in presence of 10 uM ATP | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 9. | ALA4124193 | B | Inhibition of kinase tracer-04 binding to C-terminal NanoLuc tagged full length JAK1 (unknown origin) expressed in HEK cells by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 10. | ALA4124194 | A | Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK2 (unknown origin) expressed in HEK cells by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 11. | ALA4124195 | B | Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length JAK3 (unknown origin) expressed in HEK cells by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 12. | ALA4124196 | B | Inhibition of kinase tracer-05 binding to C-terminal NanoLuc tagged full length BTK (unknown origin) expressed in HEK cells by NanoBRET assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 13. | ALA4124197 | B | Selectivity ratio of EC50 for C-terminal NanoLuc tagged full length JAK2 (unknown origin) expressed in HEK cells to EC50 for C-terminal NanoLuc tagged full length JAK3 (unknown origin) expressed in HEK cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4124206 | B | Inhibition of JAK1/JAK3 in human CD4 positive T cells assessed as inhibition of IL2-stimulated STAT5 phosphorylation at Tyr-695 residue at 100 to 300 nM preincubated for 1 hr followed by IL-2 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4124207 | B | Inhibition of JAK1/JAK3 in human CD4 positive T cells assessed as inhibition of IL4-stimulated STAT6 phosphorylation at 100 to 300 nM preincubated for 1 hr followed by IL-4 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4124208 | B | Inhibition of JAK1/TYK2 in human CD4 positive T cells assessed as inhibition of IFNalpha-stimulated STAT1 phosphorylation at Tyr-695 residue at 1000 nM preincubated for 1 hr followed by IFNalpha stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4124209 | B | Inhibition of JAK1/JAK2/TYK2 in human CD4 positive T cells assessed as inhibition of IL6-stimulated STAT3 phosphorylation at 1000 nM preincubated for 1 hr followed by IL-6 stimulation measured after 30 mins by immunoblot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4124213 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 100 uM after 180 mins in presence of NADPH regenerating system by LC-MS analysis | Mus musculus | 4 | microsome format | Scientific Literature | ||
| 19. | ALA4124214 | A | Metabolic stability in human whole blood assessed as parent compound remaining at 1 uM after 180 mins by LC-MS analysis | Homo sapiens | 4 | tissue-based format | Scientific Literature | ||
| 20. | ALA4124215 | P | Aqueous solubility in pH 7.4 PBS buffer by HPLC analysis | 4 | small-molecule physicochemical format | Scientific Literature |
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