# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4125280 | B | Inhibition of Candida albicans CYP51 assessed as reduction in [3-3H]lanosterol 14alpha-demethylation at 0.75 uM preincubated for 60 secs followed by NADPH addition measured after 60 mins by RP-HPLC analysis relative to control | Candida albicans | 17 | ALA4118269 | single protein format | Scientific Literature | |
2. | ALA4125281 | B | Inhibition of Aspergillus fumigatus CYP51 assessed as reduction in [3-3H]eburicol 14alpha-demethylation at 0.75 uM preincubated for 60 secs followed by NADPH addition measured after 60 mins by RP-HPLC analysis relative to control | Aspergillus fumigatus | 17 | ALA4118269 | assay format | Scientific Literature | |
3. | ALA4125282 | P | Lipophilicity, log P of the compound | 16 | ALA4118269 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4125283 | B | Binding affinity to Candida albicans CYP51 by spectral titration method | Candida albicans | 8 | ALA4118269 | single protein format | Scientific Literature | |
5. | ALA4125284 | B | Binding affinity to Aspergillus fumigatus CYP51 by spectral titration method | Aspergillus fumigatus | 8 | ALA4118269 | assay format | Scientific Literature | |
6. | ALA4125285 | B | Potency index, ratio of VNI Kd(app) to compound Kd(app) for Candida albicans CYP51 | Candida albicans | 7 | ALA4118269 | single protein format | Scientific Literature | |
7. | ALA4125286 | B | Potency index, ratio of VNI Kd(app) to compound Kd(app) for Aspergillus fumigatus CYP51 | Aspergillus fumigatus | 7 | ALA4118269 | assay format | Scientific Literature | |
8. | ALA4125287 | A | Intrinsic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 14 | ALA4118269 | microsome format | Scientific Literature | |
9. | ALA4125288 | A | Hepatic clearance in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 14 | ALA4118269 | microsome format | Scientific Literature | |
10. | ALA4125289 | A | Half life in human liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 14 | ALA4118269 | microsome format | Scientific Literature | |
11. | ALA4125290 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA4118269 | microsome format | Scientific Literature | |
12. | ALA4125291 | A | Hepatic clearance in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA4118269 | microsome format | Scientific Literature | |
13. | ALA4125292 | A | Half life in Sprague-Dawley rat liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA4118269 | microsome format | Scientific Literature | |
14. | ALA4125293 | A | Intrinsic clearance in CD-1 mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Mus musculus | 14 | ALA4118269 | microsome format | Scientific Literature | |
15. | ALA4125294 | A | Hepatic clearance in CD-1 mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Mus musculus | 14 | ALA4118269 | microsome format | Scientific Literature | |
16. | ALA4125295 | A | Half life in CD-1 mouse liver microsomes at 1 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Mus musculus | 14 | ALA4118269 | microsome format | Scientific Literature | |
17. | ALA4323748 | B | Inhibition of human CYP51 T314I mutant expressed in Escherichia coli at inhibitor/enzyme ratio 50/1 incubated for 1 hr using [3H] lanosterol as substrate by HPLC analysis | Homo sapiens | 6 | ALA4321832 | assay format | Scientific Literature |