| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA3436165 | Functional | Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits | Cricetulus griseus | 1 | ALA3436045 | cell-based format | Scientific Literature | |
| 2. | ALA3541780 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2J2 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 3. | ALA3541781 | ADME | Drug metabolism in supersomes expressing human recombinant CYP3A4 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 4. | ALA3541782 | ADME | Drug metabolism in supersomes expressing human recombinant CYP3A5 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 10 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 5. | ALA3541783 | ADME | Drug metabolism in supersomes expressing human recombinant CYP1A1 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 6. | ALA3541784 | ADME | Drug metabolism in supersomes expressing human recombinant CYP1A2 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 7. | ALA3541785 | ADME | Drug metabolism in supersomes expressing human recombinant CYP1B1 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 8. | ALA3541786 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C8 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 9. | ALA3541787 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C9 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 10. | ALA3541788 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C18 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 11. | ALA3541789 | ADME | Drug metabolism in supersomes expressing human recombinant CYP2C19 assessed as enzyme-mediated N-desmethylclozapine metabolite formation at 100 uM after 30 mins measured per nmol of P450 by HPLC analysis | Homo sapiens | 1 | ALA3525934 | single protein format | Scientific Literature | |
| 12. | ALA3537681 | ADME | Competitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as free enzyme by Lineweaver-Burk plot analysis | Homo sapiens | 7 | ALA3525984 | tissue-based format | Scientific Literature | |
| 13. | ALA3537682 | ADME | Uncompetitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as enzyme-substrate complex by Lineweaver-Burk plot analysis | Homo sapiens | 7 | ALA3525984 | tissue-based format | Scientific Literature | |
| 14. | ALA3537683 | ADME | Ratio of Ki for uncompetitive inhibition of human liver cytosolic aldehyde oxidase to Ki for competitive inhibition of human liver cytosolic aldehyde oxidase | Homo sapiens | 7 | ALA3525984 | assay format | Scientific Literature | |
| 15. | ALA3537687 | ADME | Unbound fraction in plasma (unknown origin) under normal atmospheric condition at pH 7.22 after 6 hrs by equilibrium dialysis method | Not specified | 22 | ALA3526113 | cell-free format | Scientific Literature | |
| 16. | ALA3537688 | ADME | Unbound fraction in plasma (unknown origin) at pH 7.4 after 6 hrs by equilibrium dialysis method in presence of 5% CO2 | Not specified | 22 | ALA3526113 | cell-free format | Scientific Literature | |
| 17. | ALA3537689 | ADME | Unbound fraction in plasma (unknown origin) at pH 7.63 after 6 hrs by equilibrium dialysis method in presence of 5% CO2 | Not specified | 22 | ALA3526113 | cell-free format | Scientific Literature | |
| 18. | ALA3537690 | ADME | Unbound fraction in plasma (unknown origin) under normal atmospheric condition at pH 7.72 after 6 hrs by equilibrium dialysis method | Not specified | 22 | ALA3526113 | cell-free format | Scientific Literature | |
| 19. | ALA3537691 | ADME | Drug recovery in plasma (unknown origin) | Not specified | 22 | ALA3526113 | cell-free format | Scientific Literature | |
| 20. | ALA3540254 | ADME | Drug metabolism in pooled human liver microsomes assessed as clozapine N-oxide metabolite formation at 100 uM after 30 mins by HPLC analysis in presence of GSH and hGST P1-1 | Homo sapiens | 1 | ALA3525934 | assay format | Scientific Literature |
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