| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4122997 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 aggregates at 2500 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 83%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 2. | ALA4122998 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring dead cells at 250 nM after 24 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 11.2%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 3. | ALA4122999 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring live cells at 250 nM after 24 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 88.2%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 4. | ALA4123000 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring dead cells at 2500 nM after 24 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 11.2%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 5. | ALA4123001 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring live cells at 2500 nM after 24 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 88.2%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 6. | ALA4123002 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring dead cells at 250 nM after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 10.6%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 7. | ALA4123003 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring live cells at 250 nM after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 89.3%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 8. | ALA4123004 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring dead cells at 2500 nM after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 10.6%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 9. | ALA4123005 | A | Cytotoxicity against human Friedreich's ataxia lymphocytes assessed as cell viability by measuring live cells at 2500 nM after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry (Rvb = 89.3%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 10. | ALA4123006 | F | Cytoprotective activity against BSO-treated human Friedreich's ataxia fibroblasts assessed as increase in cell viability incubated overnight followed by BSO addition measured after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry | Homo sapiens | 8 | ALA4118183 | assay format | Scientific Literature | |
| 11. | ALA4123007 | F | Cytoprotective activity against BSO-treated human Friedreich's ataxia fibroblasts assessed as increase in cell viability at 25 to 50 nM incubated overnight followed by BSO addition measured after 48 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry | Homo sapiens | 4 | ALA4118183 | assay format | Scientific Literature | |
| 12. | ALA4123008 | F | Cytoprotective activity against rotenone-induced cytotoxicity in human Friedreich's ataxia lymphocytes assessed as increase in cell viability at 250 to 2500 nM preincubated for 12 hrs followed by complex 1 inhibitor rotenone addition measured after 16 hrs by calceinAM ester/ethidium homodimer-1 staining based flow cytometry | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 13. | ALA4123009 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 aggregates at 250 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 83%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 14. | ALA4123010 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 monomers at 250 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 17.3%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 15. | ALA4123011 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 aggregates at 1000 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 83%) | Homo sapiens | 9 | ALA4118183 | cell-based format | Scientific Literature | |
| 16. | ALA4123012 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 monomers at 1000 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 17.3%) | Homo sapiens | 9 | ALA4118183 | cell-based format | Scientific Literature | |
| 17. | ALA4123013 | F | Induction of inner mitochondrial membrane potential depolarization in human Friedreich's ataxia lymphocytes assessed as JC-1 monomers at 2500 nM after 16 hrs by JC1-staining based flow cytometry (Rvb = 17.3%) | Homo sapiens | 8 | ALA4118183 | cell-based format | Scientific Literature | |
| 18. | ALA4123014 | F | Inhibition of DEM-induced ROS production in human Friedreich's ataxia lymphocytes incubated for 16 hrs followed by DEM treatment for 80 mins by DCFH-DA dye based flow cytometry | Homo sapiens | 5 | ALA4118183 | cell-based format | Scientific Literature | |
| 19. | ALA4123016 | B | Substrate activity at NADH-ubiquinone oxidoreductase in mouse liver mitochondrial membrane fractions assessed as induction of electron flow from complex-1 by measuring NADH oxidation at 5 uM after 5 mins in presence of complex 1 blocker rotenone at 0.1 uM using NADH and coenzyme Q1 | Mus musculus | 3 | ALA4118183 | cell membrane format | Scientific Literature | |
| 20. | ALA4123020 | F | Increase in total ATP levels in human Friedreich's ataxia lymphocytes at 0.1 to 0.5 uM after 24 hrs by bioluminescence assay | Homo sapiens | 3 | ALA4118183 | cell-based format | Scientific Literature |
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