| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158678 | B | Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Mus musculus | 80 | cell-based format | Scientific Literature | ||
| 2. | ALA4158679 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 3. | ALA4158680 | B | Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 13 | cell-based format | Scientific Literature | ||
| 4. | ALA4158687 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents by measuring reduction in time constant of channel activation in presence of 20 mM BAPTA and 150 nM Ca2+ containing internal solution by patch clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4158688 | B | Antagonist activity at TRPV1 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay | Mus musculus | 7 | assay format | Scientific Literature | ||
| 6. | ALA4158689 | B | Antagonist activity at TRPM8 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay | Mus musculus | 7 | assay format | Scientific Literature | ||
| 7. | ALA4158690 | B | Antagonist activity at TRPV1 (unknown origin) expressed in HEK cells assessed as inhibition of capsaicin-induced calcium increase at 10 uM by fura-2-based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4158691 | B | Antagonist activity at TRPM8 (unknown origin) expressed in HEK cells assessed as inhibition of menthol -mediated calcium increase at 10 uM by fura-2-based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 9. | ALA4158720 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4158721 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4158722 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4158723 | B | Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4158724 | B | Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4158725 | B | Modulation of STIM1/STIM2/Orai1 in mouse BV2 cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4158726 | B | Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in peak amplitude at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4158727 | B | Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in AUC of calcium entry at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4158728 | B | Induction of store-operated calcium entry in human Jurkat cells assessed as induction of store-operated calcium entry by measuring increase in slope at 0.3 to 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4158738 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA by patch clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 19. | ALA4158739 | B | Modulation of Orai1/STIM1 (unknown origin) expressed in HEK cells assessed as potentiation of store-operated calcium currents in presence of 20 mM BAPTA and 150 nM Ca2+ containing internal solution by patch clamp assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 20. | ALA4158740 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM in presence of shTRPC1 preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |
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