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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4149814 F Agonist activity at human GPR119 expressed in HEK293 cells assessed as increase in cAMP level after 30 mins by LANCE assay Homo sapiens 18 ALA4145595 cell-based format Scientific Literature 2. ALA4149815 F Agonist activity at mouse GPR119 assessed as increase in cAMP level Mus musculus 18 ALA4145595 assay format Scientific Literature 3. ALA4149816 F Glucose lowering effect in C57Bl/6NCrl mouse assessed as reduction in glucose level at 3 mg/kg, po administered via gavage pretreated for 30 mins followed by glucose-challenge measured after 20 mins by OGTT relative to control Mus musculus 11 ALA4145595 organism-based format Scientific Literature 4. ALA4149820 A Plasma clearance in rat at 1 mg/kg, iv or 3 mg/kg, po Rattus norvegicus 1 ALA4145595 organism-based format Scientific Literature 5. ALA4149821 A Volume of distribution at steady state in rat at 1 mg/kg, iv or 3 mg/kg, po Rattus norvegicus 1 ALA4145595 organism-based format Scientific Literature 6. ALA4149822 A Half life in rat at 1 mg/kg, iv or 3 mg/kg, po Rattus norvegicus 1 ALA4145595 organism-based format Scientific Literature 7. ALA4149823 A AUC in rat at 3 mg/kg, po Rattus norvegicus 1 ALA4145595 organism-based format Scientific Literature 8. ALA4149824 A Oral bioavailability in rat at 3 mg/kg Rattus norvegicus 1 ALA4145595 organism-based format Scientific Literature 9. ALA4149825 A Plasma clearance in monkey at 1 mg/kg, iv or 3 mg/kg, po Macaca mulatta 1 ALA4145595 organism-based format Scientific Literature 10. ALA4149826 A Volume of distribution at steady state in monkey at 1 mg/kg, iv or 3 mg/kg, po Macaca mulatta 1 ALA4145595 organism-based format Scientific Literature 11. ALA4149827 A Half life in monkey at 1 mg/kg, iv or 3 mg/kg, po Macaca mulatta 1 ALA4145595 organism-based format Scientific Literature 12. ALA4149828 A AUC in monkey at 3 mg/kg, po Macaca mulatta 1 ALA4145595 organism-based format Scientific Literature 13. ALA4149829 A Oral bioavailability in monkey at 3 mg/kg Macaca mulatta 1 ALA4145595 organism-based format Scientific Literature 14. ALA4149830 A Plasma clearance in dog at 1 mg/kg, iv or 3 mg/kg, po Canis lupus familiaris 1 ALA4145595 organism-based format Scientific Literature 15. ALA4149831 A Volume of distribution at steady state in dog at 1 mg/kg, iv or 3 mg/kg, po Canis lupus familiaris 1 ALA4145595 organism-based format Scientific Literature 16. ALA4149832 A Half life in dog at 1 mg/kg, iv or 3 mg/kg, po Canis lupus familiaris 1 ALA4145595 organism-based format Scientific Literature 17. ALA4149833 A AUC in dog at 3 mg/kg, po Canis lupus familiaris 1 ALA4145595 organism-based format Scientific Literature 18. ALA4149834 F Antidiabetic activity in C57Bl/6NCrl mouse assessed as reduction in glucose excursion administered via oral gavage pretreated for 30 mins followed by glucose-challenge measured 60 mins post dose by OGTT Mus musculus 1 ALA4145595 organism-based format Scientific Literature 19. ALA4149835 F Antidiabetic activity in C57Bl/6NCrl mouse assessed as reduction in glucose excursion at 0.03 mg/kg, po administered via gavage pretreated for 30 mins followed by glucose-challenge measured 60 mins post dose by OGTT relative to control Mus musculus 1 ALA4145595 organism-based format Scientific Literature 20. ALA4149836 F Antidiabetic activity in C57Bl/6NCrl mouse assessed as reduction in glucose excursion at 0.1 mg/kg, po administered via gavage pretreated for 30 mins followed by glucose-challenge measured 60 mins post dose by OGTT relative to control Mus musculus 1 ALA4145595 organism-based format Scientific Literature