# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4145311 | B | Displacement of [3H]-diprenorphine from human DOR expressed in CHO cell membranes after 80 mins by scintillation counting analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
2. | ALA4145312 | B | Displacement of [3H]-diprenorphine from human MOR expressed in CHO cell membranes after 80 mins by scintillation counting analysis | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
3. | ALA4145313 | B | Displacement of [3H]-diprenorphine from human mu-delta opioid receptor heterodimer expressed in CHO cell membranes at high site fraction after 80 mins by scintillation counting analysis relative to control | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
4. | ALA4145314 | B | Displacement of [3H]-diprenorphine from human mu-delta opioid receptor expressed in CHO cell membranes after 80 mins by scintillation counting analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
5. | ALA4145315 | F | Antagonist activity at human MOR expressed in CHO cell membranes mixed with human DOR expressed in CHO cell membranes assessed as inhibition of CYM51010-induced [35S]-GTPgammaS binding preincubated for 5 mins followed by CYM51010 and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
6. | ALA4145316 | B | Selectivity ratio of KiH for human mu-delta opioid receptor heterodimer expressed in CHO cell membranes to Ki for human DOR expressed in CHO cell membranes | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
7. | ALA4145317 | F | Antagonist activity at human mu-delta opioid receptor heterodimer expressed in CHO cell membranes assessed as inhibition of CYM51010-induced [35S]-GTPgammaS binding at high site fraction preincubated for 5 mins followed by CYM51010 and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
8. | ALA4145318 | F | Antagonist activity at human mu-delta opioid receptor heterodimer expressed in CHO cell membranes assessed as inhibition of CYM51010-induced [35S]-GTPgammaS binding at high site fraction preincubated for 5 mins followed by CYM51010 and [35S]-GTPgammaS addition measured after 80 mins relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
9. | ALA4145319 | F | Antagonist activity at human DOR expressed in CHO cell membranes assessed as inhibition of CYM51010-induced [35S]-GTPgammaS binding preincubated for 5 mins followed by CYM51010 and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
10. | ALA4145320 | F | Antagonist activity at human MOR expressed in CHO cell membranes assessed as inhibition of CYM51010-induced [35S]-GTPgammaS binding preincubated for 5 mins followed by CYM51010 and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
11. | ALA4145321 | B | Selectivity ratio of IC50H for human mu-delta opioid receptor heterodimer expressed in CHO cell membranes to IC50 for human DOR expressed in CHO cell membranes | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
12. | ALA4145322 | F | Antagonist activity at human mu-delta opioid receptor heterodimer expressed in CHO cell membranes assessed as inhibition of DAMGO-induced [35S]-GTPgammaS binding preincubated for 5 mins followed by DAMGO and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
13. | ALA4145323 | F | Antagonist activity at human KOR expressed in CHO cell membranes assessed as inhibition of U50488-induced [35S]-GTPgammaS binding preincubated for 5 mins followed by U50488 and [35S]-GTPgammaS addition measured after 80 mins | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
14. | ALA4145324 | F | Antinociceptive activity in icv dosed CD1 mouse assessed as reduction in CYM51010-induced nociception pretreated for 5 mins followed by CYM51010 injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4145325 | F | Antinociceptive activity in icv dosed CD1 mouse assessed as reduction in Deltorphin-2-induced nociception pretreated for 5 mins followed by Deltorphin-2 injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4145326 | F | Antinociceptive activity in CD1 mouse assessed as reduction in DAMGO-induced nociception up to10 nmol, icv pretreated for 5 mins followed by DAMGO injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4145327 | F | Antinociceptive activity in CD1 mouse assessed as reduction in DSLET-induced nociception up to 10 nmol, icv pretreated for 5 mins followed by DSLET injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4145329 | F | Antinociceptive activity in CD1 mouse assessed as reduction in morphine-induced nociception at 10 nmol pretreated for 5 mins followed by morphine injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4145330 | F | Antinociceptive activity in CD1 mouse assessed as reduction in SNC80-induced nociception at 10 nmol pretreated for 5 mins followed by SNC80 injection measured up to 2 hrs by tail flick assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
20. | ALA4145331 | F | Reduction in morphine dependence expression in acute morphine dependence ICR mouse model assessed as inhibition of naloxone-precipitated jumping behavior at 1 nmol, icv administered 5 mins prior to naloxone injection measured up to 20 mins relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |