| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4145698 | F | Growth inhibition of human NCI-H1975 cells after 72 hrs by CellTiter-Glo assay | Homo sapiens | 36 | ALA4145441 | cell-based format | Scientific Literature | |
| 2. | ALA4145699 | F | Growth inhibition of human NCI-H3122 cells after 72 hrs by CellTiter-Glo assay | Homo sapiens | 35 | ALA4145441 | cell-based format | Scientific Literature | |
| 3. | ALA4145700 | B | Inhibition of recombinant human wild-type His-tagged EGFR expressed in mammalian expression system using Tyr 4 peptide as substrate after 1 hr in presence of ATP by Z-LYTE kinase assay | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 4. | ALA4145701 | B | Inhibition of recombinant human GST-tagged EGFR L858R mutant expressed in Baculovirus expression system using Tyr 4 peptide as substrate after 1 hr in presence of ATP by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 5. | ALA4145702 | B | Inhibition of recombinant human GST-tagged EGFR T790M mutant expressed in Baculovirus expression system using Tyr 4 peptide as substrate after 1 hr in presence of ATP by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 6. | ALA4145703 | B | Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant expressed in Baculovirus expression system using Tyr 4 peptide as substrate after 1 hr in presence of ATP by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 7. | ALA4145704 | B | Inhibition of recombinant human wild-type GST-tagged ALK expressed in Baculovirus expression system using Tyr 1 peptide as substrate after 1 hr by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 8. | ALA4145705 | B | Inhibition of recombinant human N-terminal GST/His6-fused ALK R1275Q mutant expressed in Sf9 insect cells using Tyr 1 peptide as substrate after 1 hr by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | cell-based format | Scientific Literature | |
| 9. | ALA4145706 | B | Inhibition of recombinant human N-terminal GST/His6-fused ALK L1196M mutant expressed in Sf9 insect cells using Tyr 1 peptide as substrate after 1 hr by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | cell-based format | Scientific Literature | |
| 10. | ALA4145707 | B | Inhibition of recombinant human N-terminal GST/His6-fused ALK F1174L mutant expressed in Sf9 insect cells using Tyr 1 peptide as substrate after 1 hr by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | cell-based format | Scientific Literature | |
| 11. | ALA4145708 | B | Inhibition of recombinant human N-terminal GST/His6-fused ALK C1156Y mutant expressed in Sf9 insect cells using Tyr 1 peptide as substrate after 1 hr by Z-LYTE assay | Homo sapiens | 1 | ALA4145441 | cell-based format | Scientific Literature | |
| 12. | ALA4145709 | B | Selectivity index, ratio of IC50 for recombinant human GST-tagged EGFR L858R mutant to IC50 for recombinant human GST-tagged EGFR T790M mutant | Homo sapiens | 1 | ALA4145441 | assay format | Scientific Literature | |
| 13. | ALA4145710 | A | Antiproliferative activity against mouse BAF3 cells after 72 hrs by CellTiter-Glo assay | Mus musculus | 5 | ALA4145441 | cell-based format | Scientific Literature | |
| 14. | ALA4145711 | B | Inhibition of TEL-fused EGFR (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 4 | ALA4145441 | cell-based format | Scientific Literature | |
| 15. | ALA4145712 | B | Inhibition of TEL-fused EGFR C797S mutant (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 3 | ALA4145441 | cell-based format | Scientific Literature | |
| 16. | ALA4145713 | B | Inhibition of TEL-fused EGFR T790M mutant (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 4 | ALA4145441 | cell-based format | Scientific Literature | |
| 17. | ALA4145714 | B | Inhibition of full length EGFR del19 mutant (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 3 | ALA4145441 | cell-based format | Scientific Literature | |
| 18. | ALA4145715 | B | Inhibition of NPM-fused ALK (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 2 | ALA4145441 | cell-based format | Scientific Literature | |
| 19. | ALA4145716 | F | Cell cycle arrest in human NCI-H1975 cells assessed as accumulation at G0/G1 phase at 0.03 to 1 uM after 24 hrs by propidium iodide/RNase staining-based flow cytometry | Homo sapiens | 1 | ALA4145441 | cell-based format | Scientific Literature | |
| 20. | ALA4145717 | B | Inhibition of full length EGFR L858R mutant (unknown origin) expressed in mouse BAF3 cells assessed as decrease in cell proliferation after 72 hrs by CellTiter-Glo assay | Homo sapiens | 3 | ALA4145441 | cell-based format | Scientific Literature |
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