| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4144622 | A | Cytotoxicity against rat Ac2F cells assessed as reduction in cell viability up to 50 uM after 24 hrs by WST assay | Rattus norvegicus | 1 | cell-based format | Scientific Literature | ||
| 2. | ALA4144623 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability up to 50 uM after 24 hrs by WST assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4144624 | B | Agonist activity at full length human flag-tagged PPARgamma1 LBD expressed in rat Ac2F cells coexpressing PPRE-X3-TK after 6 hrs by one-glo luciferase reporter gene assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4144625 | B | Agonist activity at full length human flag-tagged PPARgamma1 LBD expressed in rat Ac2F cells coexpressing PPRE-X3-TK at 20 uM after 6 hrs by one-glo luciferase reporter gene assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4144627 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as increase in protein expression level in nuclear fractions at 30 uM after 24 hrs by Western blot assay relative to control | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4144629 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB p65 phosphorylation pretreated with compound for 1 hr followed by LPS stimulation for 30 mins by Western blot assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4144630 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB p65 phosphorylation at 30 uM pretreated with compound for 1 hr followed by LPS stimulation for 30 mins by Western blot assay relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4144632 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB p65 phosphorylation at 30 uM pretreated with compound for 1 hr followed by LPS stimulation for 30 mins in presence of PPARgamma antagonist GW9662 by Western blot assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4144633 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in iNOS mRNA level pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4144634 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in COX2 mRNA level pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4144635 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in TNFalpha mRNA level pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4144636 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in IL-1beta mRNA level pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4144637 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in IL-6 mRNA level pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4144638 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in iNOS mRNA level at 50 uM pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4144639 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in COX2 mRNA level at 50 uM pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4144640 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in TNFalpha mRNA level at 50 uM pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4144641 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in IL-1beta mRNA level at 50 uM pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4144642 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in IL-6 mRNA level at 50 uM pretreated with compound for 1 hr followed by LPS stimulation for 6 hrs by RT-PCR analysis relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 19. | ALA4144643 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in iNOS protein level pretreated with compound for 1 hr followed by LPS stimulation measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 20. | ALA4144644 | B | Agonist activity at PPARgamma in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of NF-kappaB signaling by measuring reduction in COX2 protein level pretreated with compound for 1 hr followed by LPS stimulation measured after 24 hrs by Western blot analysis | Mus musculus | 1 | cell-based format | Scientific Literature |
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