| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4151661 | B | Inhibition of GSK3beta (unknown origin) at 10 uM using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assay | Homo sapiens | 35 | single protein format | Scientific Literature | ||
| 2. | ALA4151662 | B | Inhibition of GSK3beta (unknown origin) using GS-2 peptide substrate incubated for 30 mins by kinase-Glo luminescent assay | Homo sapiens | 36 | single protein format | Scientific Literature | ||
| 3. | ALA4151663 | B | Inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by ULight-GS (Ser641/pSer657) peptide substrate addition and measured after 1 hr by TR-FRET assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 4. | ALA4151664 | B | Reversible inhibition of GSK3beta (unknown origin) pre-incubated for 30 mins followed by 100 fold dilution into buffer containing ULight-GS (Ser641/pSer657) peptide substrate and cofactors by TR-FRET assay based jump-dilution assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4151665 | B | Competitive inhibition of GSK3beta (unknown origin) at 10 uM using fixed level of GS-2 peptide substrate and varying ATP levels incubated for 30 mins by kinase-Glo luminescent assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 6. | ALA4151666 | A | Permeability in pH 7.4 PBS incubated for 2.5 hrs by PAMPA-BBB assay | 5 | assay format | Scientific Literature | |||
| 7. | ALA4151668 | T | Neurotoxicity in rat primary cerebellar granule neurons assessed as reduction in cell viability at 50 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 8. | ALA4151669 | T | Neurotoxicity in rat primary cerebellar granule neurons assessed as reduction in cell viability at 5 to 25 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 9. | ALA4151671 | T | Hepatotoxicity in human HepG2 cells assessed as reduction in cell viability at 5 to 50 uM incubated for 24 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4151672 | B | Inhibition of AcPHF6 peptide aggregation in pH 7.4 phosphate buffer assessed as reduction in fluorescence intensity at 10 uM measured every minute over 120 mins with 10 secs shaking prior to each reading by ThT fluorescence assay | 5 | assay format | Scientific Literature | |||
| 11. | ALA4151673 | B | Inhibition of AcPHF6 peptide aggregation in pH 7.4 phosphate buffer at 25 uM by CD Spectroscopy | 2 | assay format | Scientific Literature | |||
| 12. | ALA4151674 | B | Inhibition of AcPHF6 peptide aggregation in pH 7.4 phosphate buffer at 10 uM by atomic force microscopy | 2 | assay format | Scientific Literature | |||
| 13. | ALA4151675 | B | Inhibition of tau K18 fragment peptide aggregation assessed as induction of delay in K19 self aggregation at 1 to 10 uM measured every 15 mins by ThT fluorescence assay based RT-QuIC analysis | 1 | assay format | Scientific Literature | |||
| 14. | ALA4151676 | B | Inhibition of tau K18 fragment peptide aggregation assessed as reduction in K19 self aggregation at 1 to 10 uM measured every 15 mins by ThT fluorescence assay based RT-QuIC analysis | 1 | assay format | Scientific Literature | |||
| 15. | ALA4151677 | B | Inhibition of heparin-induced full-length 2N4R tau self aggregation (unknown origin) assessed as induction of delay in aggregation at 10 uM by ThT fluorescence assay based RT-QuIC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 16. | ALA4151678 | B | Inhibition of heparin-induced full-length 2N4R tau self aggregation (unknown origin) assessed as reduction in formed aggregates level at 10 uM by ThT fluorescence assay based RT-QuIC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 17. | ALA4151679 | B | Inhibition of okadaic acid-induced GSK-3beta-mediated tau hyperphosphorylation in human SH-SY5Y cells assessed as increase in cell viability pre-incubated for 1 hr before okadaic acid stimulation for 24 hrs by MTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 18. | ALA4151680 | B | Inhibition of GSK3beta (unknown origin) at 10 uM | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 19. | ALA4151681 | B | Inhibition of human recombinant CK1delta at 10 uM incubated for 60 mins by Kinase-Glo assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 20. | ALA4151682 | B | Inhibition of human recombinant CK1epsilon at 10 uM incubated for 60 mins by Kinase-Glo assay | Homo sapiens | 2 | single protein format | Scientific Literature |
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