# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4146160 | F | Antimycobacterial activity against Mycobacterium bovis BCG at 25 uM after 10 days by broth dilution method relative to control | Mycobacterium tuberculosis | 14 | ALA4145451 | organism-based format | Scientific Literature | |
2. | ALA4146161 | F | Antimycobacterial activity against Mycobacterium bovis BCG after 10 days by broth dilution method | Mycobacterium tuberculosis | 14 | ALA4145451 | organism-based format | Scientific Literature | |
3. | ALA4146162 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 10 days by broth dilution method | Mycobacterium tuberculosis | 2 | ALA4145451 | organism-based format | Scientific Literature | |
4. | ALA4146163 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTS assay | Homo sapiens | 2 | ALA4145451 | cell-based format | Scientific Literature | |
5. | ALA4146164 | A | Hemolytic activity in human RBC after 24 hrs | Homo sapiens | 2 | ALA4145451 | cell-based format | Scientific Literature | |
6. | ALA4146165 | T | Selectivity index, ratio of CC50 for cytotoxicity against human HepG2 cells to MIC90 for antimycobacterial activity against Mycobacterium tuberculosis H37Rv | 2 | ALA4145451 | cell-based format | Scientific Literature | ||
7. | ALA4146166 | B | Inhibition of Mycobacterium tuberculosis His-tagged DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs over 6 mins by spectrophotometric method | Mycobacterium tuberculosis | 5 | ALA4145451 | single protein format | Scientific Literature | |
8. | ALA4146167 | B | Inhibition of recombinant human DHFR assessed as reduction in consumption of NADPH using DHF as substrate measured every 30 secs over 6 mins by spectrophotometric method | Homo sapiens | 5 | ALA4145451 | single protein format | Scientific Literature | |
9. | ALA4146168 | B | Selectivity index, ratio of IC50 for inhibition of recombinant human DHFR to IC50 for inhibition of Mycobacterium tuberculosis His-tagged DHFR | 4 | ALA4145451 | assay format | Scientific Literature | ||
10. | ALA4146169 | F | Ratio of MIC90 for Mycobacterium bovis BCG over-expressing DHFR to MIC90 for Mycobacterium bovis BCG | Mycobacterium tuberculosis | 3 | ALA4145451 | organism-based format | Scientific Literature | |
11. | ALA4146170 | P | Aqueous solubility of compound in pH 7.4 solution after 90 mins by UV method | 2 | ALA4145451 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4146171 | A | Half life in male rat liver microsomes at 3 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4145451 | microsome format | Scientific Literature | |
13. | ALA4146172 | A | Half life in female rat liver microsomes at 3 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4145451 | microsome format | Scientific Literature | |
14. | ALA4146173 | A | Intrinsic clearance in male rat liver microsomes at 3 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4145451 | microsome format | Scientific Literature | |
15. | ALA4146174 | A | Intrinsic clearance in female rat liver microsomes at 3 uM preincubated for 5 mins followed by NADPH addition measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4145451 | microsome format | Scientific Literature |