| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4147114 | F | Inhibition of RANKL/mCSF-induced osteoclast differentiation in C57BL/6 mouse BMMC assessed as reduction in TRAP-positive multinucleated cells at 30 uM by microscopic method relative to control | Mus musculus | 5 | cell-based format | Scientific Literature | ||
| 2. | ALA4147115 | F | Inhibition of RANKL/mCSF-induced osteoclast differentiation in C57BL/6 mouse BMMC assessed as reduction in TRAP-positive multinucleated cells by microscopic method | Mus musculus | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4147116 | A | Cytotoxicity against C57BL/6 mouse BMMC up to 100 uM after 48 hrs by CCK8 assay | Mus musculus | 4 | cell-based format | Scientific Literature | ||
| 4. | ALA4147117 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli by SPR assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 5. | ALA4147118 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli assessed as association constant by SPR assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 6. | ALA4147119 | B | Binding affinity to recombinant human sRANKL expressed in Escherichia coli assessed as dissociation constant by SPR assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 7. | ALA4147120 | B | Inhibition of RANKL/RANK protein-protein interaction in mouse RAW264.7 cells assessed as reduction in RANKL-stimulated NF-kB signaling pathway activation by measuring decrease in IkBalpha phosphorylation after 2 hrs by immunoblot assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4147121 | A | Drug metabolism assessed as alpha-chymotrypsin (unknown origin)-mediated compound degradation by measuring parent compound remaining after 8 hrs by HPLC analysis | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 9. | ALA4147122 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse distal femur bone at 20 mg/kg/day, ip after 6 weeks by H and E staining based microscopic method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4147123 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse assessed as reduction in TRAP-positive multinucleated cells in distal femur bone at 20 mg/kg/day, ip after 6 weeks by microscopic method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4147124 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse distal femur bone assessed as increase in bone volume expressed per unit total volume at 20 mg/kg/day, ip after 6 weeks by micro-CT analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4147125 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse distal femur bone assessed as increase in bone surface area expressed per unit total volume at 20 mg/kg/day, ip after 6 weeks by micro-CT analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4147126 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse distal femur bone assessed as increase in trabecular number at 20 mg/kg/day, ip after 6 weeks by micro-CT analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4147127 | F | Inhibition of ovariectomy-induced trabecular bone loss in C57BL/6 mouse distal femur bone assessed as increase in bone mineral density at 20 mg/kg/day, ip after 6 weeks by micro-CT analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4147128 | F | Inhibition of osteoclastogenesis in ovariectomized C57BL/6 mouse assessed as decrease in serum IL-6 level at 20 mg/kg/day, ip after 6 weeks by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4147129 | F | Inhibition of osteoclastogenesis in ovariectomized C57BL/6 mouse assessed as decrease in serum TNFalpha level at 20 mg/kg/day, ip after 6 weeks by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4147130 | F | Inhibition of osteoclastogenesis in ovariectomized C57BL/6 mouse assessed as decrease in serum CTX-1 level at 20 mg/kg/day, ip after 6 weeks by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4147131 | F | Inhibition of osteoclastogenesis in ovariectomized C57BL/6 mouse assessed as decrease in serum TRAcp5B level at 20 mg/kg/day, ip after 6 weeks by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature |
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