| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4146049 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing lasB at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control | Pseudomonas aeruginosa PAO1 | 28 | ALA4145447 | single protein format | Scientific Literature | |
| 2. | ALA4146050 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing rhlA at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control | Pseudomonas aeruginosa PAO1 | 28 | ALA4145447 | assay format | Scientific Literature | |
| 3. | ALA4146051 | B | Inhibition of Pseudomonas aeruginosa PAO1 GFP-fused quorum sensing pqsA at 10 uM measured every 15 mins up to 12 hrs by GFP reporter gene assay relative to control | Pseudomonas aeruginosa PAO1 | 28 | ALA4145447 | single protein format | Scientific Literature | |
| 4. | ALA4146052 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 48 hrs by Griess method relative to control | Mus musculus | 28 | ALA4145447 | cell-based format | Scientific Literature | |
| 5. | ALA4146053 | A | Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 6. | ALA4146055 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 6 hrs by ELISA (Rvb = 11922 +/- 628.4 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 7. | ALA4146056 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA (Rvb = 21561.3 +/- 857 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 8. | ALA4146057 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs by ELISA (Rvb = 24216 +/- 498.7 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 9. | ALA4146058 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 6 hrs by ELISA (Rvb = 94.6 +/- 5.9 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 10. | ALA4146059 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 12 hrs by ELISA (Rvb = 175.2 +/- 10.2 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 11. | ALA4146060 | F | Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production by measuring TNF-alpha level at 10 uM preincubated for 2 hrs followed by LPS stimulation and measured after 24 hrs by ELISA (Rvb = 407.6 +/- 16.7 pg/ml) | Mus musculus | 4 | ALA4145447 | cell-based format | Scientific Literature | |
| 12. | ALA4146061 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kB p65 phosphorylation at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 13. | ALA4146062 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced IkB-alpha phosphorylation at Ser32/36 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 14. | ALA4146063 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced ERk1/2 phosphorylation at Thr202/Tyr204 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 15. | ALA4146064 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced MAPK p38 phosphorylation at Thr180/Tyr182 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 16. | ALA4146065 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced NF-kB p65 phosphorylation at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs in presence of PPARgamma antagonist GW9662 by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 17. | ALA4146066 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced IkB-alpha phosphorylation at Ser32/36 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs in presence of PPARgamma antagonist GW9662 by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 18. | ALA4146067 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced ERk1/2 phosphorylation at Thr202/Tyr204 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs in presence of PPARgamma antagonist GW9662 by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 19. | ALA4146068 | B | Agonist activity at PPARgamma in mouse RAW264.7 cells assessed as inhibition of LPS-induced MAPK p38 phosphorylation at Thr180/Tyr182 residues at 10 uM preincubated for 1 hr followed by LPS stimulation and measured after 4 hrs in presence of PPARgamma antagonist GW9662 by Western blot analysis | Mus musculus | 2 | ALA4145447 | cell-based format | Scientific Literature | |
| 20. | ALA4146069 | A | Growth inhibition of Pseudomonas aeruginosa PAO1 at 5 to 100 uM measured every 15 mins up to 12 hrs | Pseudomonas aeruginosa | 2 | ALA4145447 | organism-based format | Scientific Literature |
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