# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4151790 | B | Antagonist activity at human GR expressed in CHO-K1 cells assessed as reduction in dexamethasone-induced response incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 28 | ALA4145686 | cell-based format | Scientific Literature | |
2. | ALA4151791 | A | Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 28 | ALA4145686 | cell-based format | Scientific Literature | |
3. | ALA4151792 | A | Agonist activity at human GR expressed in CHO-K1 cells incubated for 20 hrs by luciferase reporter gene assay relative to dexamethasone | Homo sapiens | 28 | ALA4145686 | cell-based format | Scientific Literature | |
4. | ALA4151793 | A | Agonist activity at AR (unknown origin) expressed in human LNCaP cells incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 28 | ALA4145686 | cell-based format | Scientific Literature | |
5. | ALA4151794 | A | Agonist activity at AR (unknown origin) expressed in human LNCaP cells incubated for 20 hrs by luciferase reporter gene assay relative to mifepristone | Homo sapiens | 28 | ALA4145686 | cell-based format | Scientific Literature | |
6. | ALA4151795 | A | Antagonist activity at AR (unknown origin) expressed in human LNCaP cells assessed as reduction in R1881-induced response incubated for 20 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4145686 | cell-based format | Scientific Literature | |
7. | ALA4151796 | A | Agonist activity at AR in human LNAR cells assessed as increase in PSA gene expression at 100 nM incubated for 24 hrs by RT-qPCR method | Homo sapiens | 2 | ALA4145686 | cell-based format | Scientific Literature | |
8. | ALA4151797 | A | Agonist activity at AR in human LNAR cells assessed as increase in TMPRSS2 gene expression at 100 nM incubated for 24 hrs by RT-qPCR method | Homo sapiens | 2 | ALA4145686 | cell-based format | Scientific Literature | |
9. | ALA4151804 | A | Agonist activity at AR in human MDA-MB-453 cells assessed as increase in CLDN8 gene expression at 111 to 333 nM incubated for 24 hrs by RT-qPCR method | Homo sapiens | 2 | ALA4145686 | cell-based format | Scientific Literature | |
10. | ALA4151805 | A | Agonist activity at AR in human MDA-MB-453 cells assessed as increase in CYPGF8 gene expression at 111 to 333 nM incubated for 24 hrs by RT-qPCR method | Homo sapiens | 2 | ALA4145686 | cell-based format | Scientific Literature | |
11. | ALA4151806 | A | Agonist activity at AR in human MDA-MB-453 cells assessed as increase in SEC14L2 gene expression at 111 to 333 nM incubated for 24 hrs by RT-qPCR method | Homo sapiens | 2 | ALA4145686 | cell-based format | Scientific Literature | |
12. | ALA4151807 | A | Clearance in rat at 0.5 mg/kg, iv | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
13. | ALA4151808 | A | Volume of distribution at steady state in rat at 0.5 mg/kg, iv | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
14. | ALA4151809 | A | Half life in rat at 0.5 mg/kg, iv | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
15. | ALA4151810 | A | Oral bioavailability in rat at 5 mg/kg | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
16. | ALA4151811 | A | Cmax in rat at 5 mg/kg, po | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
17. | ALA4151812 | A | AUC in rat at 5 mg/kg, po | Rattus norvegicus | 8 | ALA4145686 | organism-based format | Scientific Literature | |
18. | ALA4151813 | A | Clearance in mouse at 0.5 mg/kg, iv | Mus musculus | 1 | ALA4145686 | organism-based format | Scientific Literature | |
19. | ALA4151814 | A | Clearance in mini pig at 0.5 mg/kg, iv | Sus scrofa | 1 | ALA4145686 | organism-based format | Scientific Literature | |
20. | ALA4151815 | A | Volume of distribution at steady state in mouse at 0.5 mg/kg, iv | Mus musculus | 1 | ALA4145686 | organism-based format | Scientific Literature |