| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4133145 | B | Antagonist activity at human P2X7 receptor expressed in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake at 10 uM after 30 mins by FLIPR assay relative to 1 mM ATP | Homo sapiens | 51 | assay format | Scientific Literature | ||
| 2. | ALA4133146 | T | Toxicity in Swiss mouse peritoneal macrophages assessed as LDH release at 10 uM after 60 mins relative to 0.05% Triton X-100 | Mus musculus | 51 | cell-based format | Scientific Literature | ||
| 3. | ALA4133147 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake at 10 uM preincubated for 10 mins followed by ATP addition measured after 20 mins by FLIPR assay relative to 1 mM ATP | Homo sapiens | 51 | cell-based format | Scientific Literature | ||
| 4. | ALA4133148 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced propidium iodide uptake after 25 mins by flow cytometric analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 5. | ALA4133149 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by ATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 8 | single protein format | Scientific Literature | ||
| 6. | ALA4133150 | A | Cytotoxicity against Swiss mouse peritoneal macrophages after 24 hrs by LDH-release assay | Mus musculus | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA4133151 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced ethidium iodide uptake preincubated for 10 mins followed by ATP addition measured after 20 mins by spectrofluorometric analysis | Homo sapiens | 9 | cell-based format | Scientific Literature | ||
| 8. | ALA4133152 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced ethidium iodide uptake after 30 mins by spectrofluorometric analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4133153 | B | Antagonist activity at P2X7 receptor in Swiss mouse peritoneal macrophages assessed as inhibition of BzATP-induced current at holding potential of -60 mV preincubated for 5 mins followed by BzATP addition measured after 5 mins by Whole cell patch-clamp analysis | Mus musculus | 3 | single protein format | Scientific Literature | ||
| 10. | ALA4133154 | B | Antagonist activity at P2X7 receptor in LPS/IFNc-differentiated human THP-1 cells assessed as inhibition of ATP-induced IL-1beta release preincubated for 30 mins followed by LPS stimulation for 4 hrs using cells treated with ATP for 30 mins by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 11. | ALA4133155 | B | Antagonist activity at P2X7 receptor in LPS/IFNc-differentiated Swiss mouse peritoneal macrophages assessed as inhibition of ATP-induced IL-1beta release preincubated for 30 mins followed by LPS stimulation for 4 hrs using cells treated with ATP for 15 mins by ELISA | Mus musculus | 2 | assay format | Scientific Literature | ||
| 12. | ALA4133156 | B | Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of ATP-induced IL-1beta release preincubated for 30 mins followed by ATP addition measured after 30 mins by ELISA | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 13. | ALA4133157 | A | Drug metabolism assessed as CYP1A2 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 14. | ALA4133158 | A | Drug metabolism assessed as CYP2C9 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 15. | ALA4133159 | A | Drug metabolism assessed as CYP2C19 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 16. | ALA4133160 | A | Drug metabolism assessed as CYP2D6 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 17. | ALA4133161 | A | Drug metabolism assessed as CYP3A4 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 18. | ALA4133162 | A | Drug metabolism assessed as UGT1A1 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 19. | ALA4133163 | A | Drug metabolism assessed as UGT1A3 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 20. | ALA4133164 | A | Drug metabolism assessed as UGT1A4 (unknown origin)-mediated metabolite formation | Homo sapiens | 4 | single protein format | Scientific Literature |
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