| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4158679 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity at 10 uM preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
| 2. | ALA4158682 | B | Modulation of TRPC1/TRPC3/STIM1/Orai1 in HEK cells assessed as induction of store-operated calcium entry by measuring residual activity preincubated for 30 mins followed by tBhQ-mediated Ca2+ depletion and Ca2+ re-addition to extracellular solution measured for 600 secs by Fluo-4 AM-based fluorometric assay relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 3. | ALA4158685 | A | Cytotoxicity against HEK cells assessed as cell viability at 10 uM by MTT assay relative to control | Homo sapiens | 25 | cell-based format | Scientific Literature | ||
| 4. | ALA4158688 | B | Antagonist activity at TRPV1 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay | Mus musculus | 7 | assay format | Scientific Literature | ||
| 5. | ALA4158689 | B | Antagonist activity at TRPM8 in C57/BL6 mouse cerebellar granule cells assessed as inhibition of KCl-induced voltage dependent calcium entry at 10 uM by fura-2-based assay | Mus musculus | 7 | assay format | Scientific Literature | ||
| 6. | ALA4158690 | B | Antagonist activity at TRPV1 (unknown origin) expressed in HEK cells assessed as inhibition of capsaicin-induced calcium increase at 10 uM by fura-2-based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 7. | ALA4158691 | B | Antagonist activity at TRPM8 (unknown origin) expressed in HEK cells assessed as inhibition of menthol -mediated calcium increase at 10 uM by fura-2-based assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 8. | ALA4158692 | A | Metabolic stability in CD1 mouse plasma assessed as residual compound level at 50 uM after 30 mins by LC-UV analysis | Mus musculus | 24 | cell-free format | Scientific Literature | ||
| 9. | ALA4158693 | A | Drug metabolism in CD1 mouse liver microsomes assessed as ester group hydrolysis at 50 uM after 60 mins in presence of NADPH/UDPGA | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 10. | ALA4158694 | A | Drug metabolism in CD1 mouse liver microsomes assessed as ester group hydrolysis at 50 uM after 60 mins in absence of NADPH/UDPGA | Mus musculus | 2 | microsome format | Scientific Literature | ||
| 11. | ALA4158695 | A | Drug metabolism in CD1 mouse liver microsomes assessed as (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(3-(1-(4-(4-(isopropoxycarbonyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-1H-1,2,3-triazol-4-yl)benzoyloxy)tetrahydro-2H-pyran-2-carboxylic acid metabolite formation at 50 uM after 60 mins by mass spectroscopic analysis | Mus musculus | 1 | microsome format | Scientific Literature | ||
| 12. | ALA4158699 | A | Metabolic stability in CD1 mouse liver S9 fraction assessed as residual compound level at 50 uM after 1 hr | Mus musculus | 2 | subcellular format | Scientific Literature | ||
| 13. | ALA4158745 | A | Drug metabolism in CD1 mouse liver microsomes assessed as 1-(4-(4-(3-Carboxyphenyl)-1H-1,2,3-triazol-1-yl)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acid metabolite formation at 50 uM after 60 mins by mass spectroscopic analysis | Mus musculus | 3 | microsome format | Scientific Literature |
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