| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4143180 | F | Anti-asthmatic activity in guinea pig tracheal smooth muscle ring assessed as reduction in acetylcholine-induced muscle contractions by measuring muscle relaxation at 0.75 mmol/l after 60 mins (Rvb = 7.73 +/- 4.81%) | Cavia porcellus | 21 | ALA4138217 | tissue-based format | Scientific Literature | |
| 2. | ALA4143181 | F | Anti-asthmatic activity in guinea pig tracheal smooth muscle ring assessed as reduction in acetylcholine-induced muscle contractions by measuring muscle relaxation at 1.25 mmol/l after 60 mins (Rvb = 13.59 +/- 9.14%) | Cavia porcellus | 21 | ALA4138217 | tissue-based format | Scientific Literature | |
| 3. | ALA4143182 | F | Anti-asthmatic activity in guinea pig tracheal smooth muscle ring assessed as reduction in acetylcholine-induced muscle contractions after 60 mins | Cavia porcellus | 21 | ALA4138217 | tissue-based format | Scientific Literature | |
| 4. | ALA4143183 | F | Agonist activity at beta-adrenergic receptor in rat airway smooth muscle cells assessed as reduction in acetylcholine-induced muscle contractions by measuring cAMP levels after 18 hrs post acetylcholine stimulation by ELISA (Rvb = 8.402 +/- 0.041 nmol/l) | Rattus norvegicus | 9 | ALA4138217 | assay format | Scientific Literature | |
| 5. | ALA4143184 | F | Anti-asthmatic activity in ovalbumin-induced asthmatic Sprague-Dawley rat model assessed as improvement in lung function by measuring dynamic compliance of the airway at 1.6 g/kg, po co-administered with OVA from day 15 to 21 of experiment period (Rvb = 0.46 +/- 0.17 No_unit) | Rattus norvegicus | 2 | ALA4138217 | organism-based format | Scientific Literature | |
| 6. | ALA4143185 | F | Anti-asthmatic activity in ovalbumin-induced asthmatic Sprague-Dawley rat model assessed as improvement in lung function by measuring airway resistance at 1.6 g/kg, po co-administered with OVA from day 15 to 21 of experiment period (Rvb = 67.33 +/- 10.54 No_unit) | Rattus norvegicus | 2 | ALA4138217 | organism-based format | Scientific Literature | |
| 7. | ALA4143190 | F | Anti-asthmatic activity in ovalbumin-induced asthmatic Sprague-Dawley rat model assessed as IL-14 levels in serum at 1.6 g/kg, po co-administered with OVA from day 15 to 21 of experiment period (Rvb = 16.04 +/- 1.41 pg/ml) | Rattus norvegicus | 2 | ALA4138217 | organism-based format | Scientific Literature | |
| 8. | ALA4143193 | F | Anti-asthmatic activity in ovalbumin-induced asthmatic Sprague-Dawley rat model assessed as IL-17 levels in serum at 1.6 g/kg, po co-administered with OVA from day 15 to 21 of experiment period (Rvb = 16.85 +/- 1.13 pg/ml) | Rattus norvegicus | 2 | ALA4138217 | organism-based format | Scientific Literature |
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